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Review: High temperature short time treatment of cell culture media and feed solutions to mitigate adventitious viral contamination in the biopharmaceutical industry

Djemal, Leila ; Fournier, Clemence ; Hagen, Joerg von ; Kolmar, Harald ; Deparis, Véronique (2021)
Review: High temperature short time treatment of cell culture media and feed solutions to mitigate adventitious viral contamination in the biopharmaceutical industry.
In: Biotechnology Progress, 37 (3)
doi: 10.1002/btpr.3117
Artikel, Bibliographie

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Kurzbeschreibung (Abstract)

Events of viral contaminations occurring during the production of biopharmaceuticals have been publicly reported by the biopharmaceutical industry. Upstream raw materials were often identified as the potential source of contamination. Viral contamination risk can be mitigated by inactivating or eliminating potential viruses of cell culture media and feed solutions. Different methods can be used alone or in combination on raw materials, cell culture media, or feed solutions such as viral inactivation technologies consisting mainly of high temperature short time, ultraviolet irradiation, and gamma radiation technologies or such as viral removal technology for instance nanofiltration. The aim of this review is to present the principle, the advantages, and the challenges of high temperature short time (HTST) technology. Here, we reviewed effectiveness of HTST treatment and its impact on media (filterability of media, degradation of components), on process performance (cell growth, cell metabolism, productivity), and product quality based on knowledge shared in the literature.

Typ des Eintrags: Artikel
Erschienen: 2021
Autor(en): Djemal, Leila ; Fournier, Clemence ; Hagen, Joerg von ; Kolmar, Harald ; Deparis, Véronique
Art des Eintrags: Bibliographie
Titel: Review: High temperature short time treatment of cell culture media and feed solutions to mitigate adventitious viral contamination in the biopharmaceutical industry
Sprache: Englisch
Publikationsjahr: 2021
Ort: Malden, MA
Verlag: Wiley
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Biotechnology Progress
Jahrgang/Volume einer Zeitschrift: 37
(Heft-)Nummer: 3
Kollation: 9 Seiten
DOI: 10.1002/btpr.3117
Zugehörige Links:
Kurzbeschreibung (Abstract):

Events of viral contaminations occurring during the production of biopharmaceuticals have been publicly reported by the biopharmaceutical industry. Upstream raw materials were often identified as the potential source of contamination. Viral contamination risk can be mitigated by inactivating or eliminating potential viruses of cell culture media and feed solutions. Different methods can be used alone or in combination on raw materials, cell culture media, or feed solutions such as viral inactivation technologies consisting mainly of high temperature short time, ultraviolet irradiation, and gamma radiation technologies or such as viral removal technology for instance nanofiltration. The aim of this review is to present the principle, the advantages, and the challenges of high temperature short time (HTST) technology. Here, we reviewed effectiveness of HTST treatment and its impact on media (filterability of media, degradation of components), on process performance (cell growth, cell metabolism, productivity), and product quality based on knowledge shared in the literature.

Freie Schlagworte: contamination, flash pasteurization, high temperature short time, precipitation, virus
Sachgruppe der Dewey Dezimalklassifikatin (DDC): 500 Naturwissenschaften und Mathematik > 540 Chemie
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
Fachbereich(e)/-gebiet(e): 07 Fachbereich Chemie
07 Fachbereich Chemie > Clemens-Schöpf-Institut > Fachgebiet Biochemie
07 Fachbereich Chemie > Clemens-Schöpf-Institut
Hinterlegungsdatum: 21 Aug 2024 05:26
Letzte Änderung: 21 Aug 2024 05:26
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