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Formal Methods for the Synthesis of Biomolecular Circuits

Benenson, Yaakov ; Dalchau, Neil ; Koeppl, Heinz ; Maler, Oded (2018)
Formal Methods for the Synthesis of Biomolecular Circuits.
In: Dagstuhl Reports, 8 (2)
doi: 10.4230/DagRep.8.2.88
Artikel, Bibliographie

Dies ist die neueste Version dieses Eintrags.

Kurzbeschreibung (Abstract)

This report documents the program and the outcomes of Dagstuhl Seminar 18082 "Formal Methods for the Synthesis of Biomolecular Circuits". Synthetic biology aims for the rational bottom-up engineering of new biological functionalities. Recent years have witnessed an increase in the degree of "rationality" in the design of synthetic biomolecular circuits. With it, fewer design-build-test cycles were necessary to achieve a desired circuit performance. Most of these success stories reported the realization of logic circuits, typically operating via regulation of gene expression and/or direct manipulation of DNA sequences with recombinases, executing combinatorial and sometimes sequential logic. This was often achieved with the help of two ingredients, a library of previously well-characterized parts and some computational modeling. Hence, although circuits in synthetic biology are still by far less understood and characterized than electronic circuits, the opportunity for the formal synthesis of circuit designs with respect to a behavioral specification starts to emerge in synthetic biology.

Typ des Eintrags: Artikel
Erschienen: 2018
Autor(en): Benenson, Yaakov ; Dalchau, Neil ; Koeppl, Heinz ; Maler, Oded
Art des Eintrags: Bibliographie
Titel: Formal Methods for the Synthesis of Biomolecular Circuits
Sprache: Englisch
Publikationsjahr: 2018
Ort: Wadern
Verlag: Schloss Dagstuhl
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Dagstuhl Reports
Jahrgang/Volume einer Zeitschrift: 8
(Heft-)Nummer: 2
Veranstaltungstitel: Dagstuhl Seminar
Veranstaltungsort: Dagstuhl, Wadern
Veranstaltungsdatum: 18.02. - 23.02.2018
DOI: 10.4230/DagRep.8.2.88
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Kurzbeschreibung (Abstract):

This report documents the program and the outcomes of Dagstuhl Seminar 18082 "Formal Methods for the Synthesis of Biomolecular Circuits". Synthetic biology aims for the rational bottom-up engineering of new biological functionalities. Recent years have witnessed an increase in the degree of "rationality" in the design of synthetic biomolecular circuits. With it, fewer design-build-test cycles were necessary to achieve a desired circuit performance. Most of these success stories reported the realization of logic circuits, typically operating via regulation of gene expression and/or direct manipulation of DNA sequences with recombinases, executing combinatorial and sometimes sequential logic. This was often achieved with the help of two ingredients, a library of previously well-characterized parts and some computational modeling. Hence, although circuits in synthetic biology are still by far less understood and characterized than electronic circuits, the opportunity for the formal synthesis of circuit designs with respect to a behavioral specification starts to emerge in synthetic biology.

Freie Schlagworte: Synthetic biology, Electronic design automation, Program synthesis and verification
ID-Nummer: Seminar-ID: 18082
Sachgruppe der Dewey Dezimalklassifikatin (DDC): 000 Allgemeines, Informatik, Informationswissenschaft > 004 Informatik
500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie
600 Technik, Medizin, angewandte Wissenschaften > 621.3 Elektrotechnik, Elektronik
Fachbereich(e)/-gebiet(e): 18 Fachbereich Elektrotechnik und Informationstechnik
18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik > Bioinspirierte Kommunikationssysteme
18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Nachrichtentechnik
18 Fachbereich Elektrotechnik und Informationstechnik > Self-Organizing Systems Lab
Hinterlegungsdatum: 02 Aug 2024 13:17
Letzte Änderung: 02 Aug 2024 13:17
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