Bagherabadi, Mohadeseh ; Fleckenstein, Marie ; Moskalyk, Oleksandr ; Belluati, Andrea ; Avrutina, Olga ; Andrieu-Brunsen, Annette (2025)
Grafting and controlled release of antimicrobial peptides from mesoporous silica.
In: Journal of Materials Chemistry B, 2024
doi: 10.26083/tuprints-00027823
Artikel, Zweitveröffentlichung, Postprint
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Kurzbeschreibung (Abstract)
The grafting of antimicrobial peptides onto mesoporous silica particles and their controlled release using a green light-responsive linker, which enables tunable release-concentration-time profiles, is presented. The mesoporous silica surface is functionalized with antimicrobial peptides employing sequential functionalization steps, including the grafting of 3-[(2-propynylcarbamate)propyl]triethoxysilane (PPTEOS) as anchor, boron-dipyrromethene (BODIPY) as photosensitive linker, and C14R peptides as antimicrobial agents. Characterization using scanning electron microscopy (SEM), transmission electron microscopy (TEM), attenuated total reflectance infrared (ATR-IR) spectroscopy, and thermogravimetric analysis (TGA) validate the successful fabrication and functionalization of mesoporous silica. The ester-1,2,3-triazole-BODIPY demonstrates high sensitivity to green light and enables C14R antimicrobial peptide release with adjusted concentration-time profiles. Under the applied conditions up to 64 μg mL⁻¹ were released within 40 minutes. The antimicrobial activity of the released C14R on Escherichia coli. BL21(DE3) is demonstrated. Overall, the use of the photosensitive linker not only provides a promising avenue for controlling the release of biomolecules and therapeutics but also opens up opportunities for the development of materials for targeted release in wound dressings, for example.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2025 |
| Autor(en): | Bagherabadi, Mohadeseh ; Fleckenstein, Marie ; Moskalyk, Oleksandr ; Belluati, Andrea ; Avrutina, Olga ; Andrieu-Brunsen, Annette |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Grafting and controlled release of antimicrobial peptides from mesoporous silica |
| Sprache: | Englisch |
| Publikationsjahr: | 30 Juli 2025 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2024 |
| Ort der Erstveröffentlichung: | Cambridge |
| Verlag: | Royal Society of Chemistry |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of Materials Chemistry B |
| Kollation: | 32 Seiten |
| DOI: | 10.26083/tuprints-00027823 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/27823 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichungsservice |
| Kurzbeschreibung (Abstract): | The grafting of antimicrobial peptides onto mesoporous silica particles and their controlled release using a green light-responsive linker, which enables tunable release-concentration-time profiles, is presented. The mesoporous silica surface is functionalized with antimicrobial peptides employing sequential functionalization steps, including the grafting of 3-[(2-propynylcarbamate)propyl]triethoxysilane (PPTEOS) as anchor, boron-dipyrromethene (BODIPY) as photosensitive linker, and C14R peptides as antimicrobial agents. Characterization using scanning electron microscopy (SEM), transmission electron microscopy (TEM), attenuated total reflectance infrared (ATR-IR) spectroscopy, and thermogravimetric analysis (TGA) validate the successful fabrication and functionalization of mesoporous silica. The ester-1,2,3-triazole-BODIPY demonstrates high sensitivity to green light and enables C14R antimicrobial peptide release with adjusted concentration-time profiles. Under the applied conditions up to 64 μg mL⁻¹ were released within 40 minutes. The antimicrobial activity of the released C14R on Escherichia coli. BL21(DE3) is demonstrated. Overall, the use of the photosensitive linker not only provides a promising avenue for controlling the release of biomolecules and therapeutics but also opens up opportunities for the development of materials for targeted release in wound dressings, for example. |
| Freie Schlagworte: | antimicrobial peptide, green light, biofunctionalization, photo-controlled release, mesoporous silica |
| Status: | Postprint |
| URN: | urn:nbn:de:tuda-tuprints-278234 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Ernst-Berl-Institut 07 Fachbereich Chemie > Ernst-Berl-Institut > Fachgebiet Makromolekulare Chemie |
| Hinterlegungsdatum: | 01 Aug 2024 12:35 |
| Letzte Änderung: | 30 Aug 2024 07:55 |
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| Suche nach Titel in: | TUfind oder in Google |
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- Grafting and controlled release of antimicrobial peptides from mesoporous silica. (deposited 01 Aug 2024 12:35) [Gegenwärtig angezeigt]
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