Sethmann, Ingo ; Luft, Cornelia ; Kleebe, Hans-Joachim (2018)
Development of Phosphatized Calcium Carbonate Biominerals as Bioactive Bone Graft Substitute Materials. Part I: Incorporation of Magnesium and Strontium Ions.
In: Journal of Functional Biomaterials, 9 (4)
doi: 10.3390/jfb9040069
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
Synthetic materials based on calcium phosphate (CaP) are frequently used as bone graft substitutes when natural bone grafts are not available or not suitable. Chemical similarity to bone guarantees the biocompatibility of synthetic CaP materials, whereas macroporosity enables their integration into the natural bone tissue. To restore optimum mechanical performance after the grafting procedure, gradual resorption of CaP implants and simultaneous replacement by natural bone is desirable. Mg and Sr ions released from implants support osteointegration by stimulating bone formation. Furthermore, Sr ions counteract osteoporotic bone loss and reduce the probability of related fractures. The present study aimed at developing porous Ca carbonate biominerals into novel CaP-based, bioactive bone implant materials. Macroporous Ca carbonate biominerals, specifically skeletons of corals (aragonite) and sea urchins (Mg-substituted calcite), were hydrothermally converted into pseudomorphic CaP materials with their natural porosity preserved. Sr ions were introduced to the mineral replacement reactions by temporarily stabilizing them in the hydrothermal phosphate solutions as Sr-EDTA complexes. In this reaction system, Na, Mg, and Sr ions favored the formation of correspondingly substituted �-tricalcium phosphate over hydroxyapatite. Upon dissolution, the incorporated functional ions became released, endowing these CaP materials with bioactive and potentially osteoporotic properties.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2018 |
| Autor(en): | Sethmann, Ingo ; Luft, Cornelia ; Kleebe, Hans-Joachim |
| Art des Eintrags: | Bibliographie |
| Titel: | Development of Phosphatized Calcium Carbonate Biominerals as Bioactive Bone Graft Substitute Materials. Part I: Incorporation of Magnesium and Strontium Ions |
| Sprache: | Englisch |
| Publikationsjahr: | 2018 |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of Functional Biomaterials |
| Jahrgang/Volume einer Zeitschrift: | 9 |
| (Heft-)Nummer: | 4 |
| DOI: | 10.3390/jfb9040069 |
| URL / URN: | https://www.mdpi.com/2079-4983/9/4/69 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | Synthetic materials based on calcium phosphate (CaP) are frequently used as bone graft substitutes when natural bone grafts are not available or not suitable. Chemical similarity to bone guarantees the biocompatibility of synthetic CaP materials, whereas macroporosity enables their integration into the natural bone tissue. To restore optimum mechanical performance after the grafting procedure, gradual resorption of CaP implants and simultaneous replacement by natural bone is desirable. Mg and Sr ions released from implants support osteointegration by stimulating bone formation. Furthermore, Sr ions counteract osteoporotic bone loss and reduce the probability of related fractures. The present study aimed at developing porous Ca carbonate biominerals into novel CaP-based, bioactive bone implant materials. Macroporous Ca carbonate biominerals, specifically skeletons of corals (aragonite) and sea urchins (Mg-substituted calcite), were hydrothermally converted into pseudomorphic CaP materials with their natural porosity preserved. Sr ions were introduced to the mineral replacement reactions by temporarily stabilizing them in the hydrothermal phosphate solutions as Sr-EDTA complexes. In this reaction system, Na, Mg, and Sr ions favored the formation of correspondingly substituted �-tricalcium phosphate over hydroxyapatite. Upon dissolution, the incorporated functional ions became released, endowing these CaP materials with bioactive and potentially osteoporotic properties. |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 550 Geowissenschaften |
| Fachbereich(e)/-gebiet(e): | 11 Fachbereich Material- und Geowissenschaften 11 Fachbereich Material- und Geowissenschaften > Geowissenschaften |
| Hinterlegungsdatum: | 02 Jul 2024 23:05 |
| Letzte Änderung: | 02 Jul 2024 23:05 |
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| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
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Development of Phosphatized Calcium Carbonate Biominerals as Bioactive Bone Graft Substitute Materials. Part I: Incorporation of Magnesium and Strontium Ions. (deposited 20 Jan 2019 20:55)
- Development of Phosphatized Calcium Carbonate Biominerals as Bioactive Bone Graft Substitute Materials. Part I: Incorporation of Magnesium and Strontium Ions. (deposited 02 Jul 2024 23:05) [Gegenwärtig angezeigt]
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