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First experimental time-of-flight-based proton radiography using low gain avalanche diodes

Ulrich-Pur, Felix ; Bergauer, Thomas ; Galatyuk, Tetyana ; Hirtl, Albert ; Kausel, Matthias ; Kedych, Vadym ; Kis, Mladen ; Kozymka, Yevhen ; Krüger, Wilhelm ; Linev, Sergey ; Michel, Jan ; Pietraszko, Jerzy ; Rost, Adrian ; Schmidt, Christian Joachim ; Träger, Michael ; Traxler, Michael (2024)
First experimental time-of-flight-based proton radiography using low gain avalanche diodes.
In: Physics in Medicine & Biology, 69 (7)
doi: 10.1088/1361-6560/ad3326
Artikel, Bibliographie

Kurzbeschreibung (Abstract)

Objective. Ion computed tomography (iCT) is an imaging modality for the direct determination of the relative stopping power (RSP) distribution within a patient's body. Usually, this is done by estimating the path and energy loss of ions traversing the scanned volume utilising a tracking system and a separate residual energy detector. This study, on the other hand, introduces the first experimental study of a novel iCT approach based on time-of-flight (TOF) measurements, the so-called Sandwich TOF-iCT concept, which in contrast to any other iCT systems, does not require a residual energy detector for the RSP determination. Approach. A small Sandwich TOF-iCT demonstrator was built based on low gain avalanche diodes (LGADs), which are 4D-tracking detectors that allow to simultaneously measure the particle position and time-of-arrival with a precision better than 100 μm and 100 ps, respectively. Using this demonstrator, the material and energy-dependent TOF was measured for several homogeneous PMMA slabs in order to calibrate the acquired TOF against the corresponding water equivalent thickness (WET). With this calibration, two proton radiographs (pRads) of a small aluminium stair phantom were recorded at MedAustron using 83 MeV and 100.4 MeV protons. Main results. Due to the simplified WET calibration models used in this very first experimental study of this novel approach, the difference between the measured and theoretical WET ranged between 37.09% and 51.12%. Nevertheless, the first TOF-based pRad was successfully recorded showing that LGADs are suitable detector candidates for Sandwich TOF-iCT. Significance. While the system parameters and WET estimation algorithms require further optimization, this work was an important first step to realize Sandwich TOF-iCT. Due to its compact and cost-efficient design, Sandwich TOF-iCT has the potential to make iCT more feasible and attractive for clinical application, which, eventually, could enhance the treatment planning quality.

Typ des Eintrags: Artikel
Erschienen: 2024
Autor(en): Ulrich-Pur, Felix ; Bergauer, Thomas ; Galatyuk, Tetyana ; Hirtl, Albert ; Kausel, Matthias ; Kedych, Vadym ; Kis, Mladen ; Kozymka, Yevhen ; Krüger, Wilhelm ; Linev, Sergey ; Michel, Jan ; Pietraszko, Jerzy ; Rost, Adrian ; Schmidt, Christian Joachim ; Träger, Michael ; Traxler, Michael
Art des Eintrags: Bibliographie
Titel: First experimental time-of-flight-based proton radiography using low gain avalanche diodes
Sprache: Englisch
Publikationsjahr: 7 April 2024
Verlag: IOP Press
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Physics in Medicine & Biology
Jahrgang/Volume einer Zeitschrift: 69
(Heft-)Nummer: 7
DOI: 10.1088/1361-6560/ad3326
Kurzbeschreibung (Abstract):

Objective. Ion computed tomography (iCT) is an imaging modality for the direct determination of the relative stopping power (RSP) distribution within a patient's body. Usually, this is done by estimating the path and energy loss of ions traversing the scanned volume utilising a tracking system and a separate residual energy detector. This study, on the other hand, introduces the first experimental study of a novel iCT approach based on time-of-flight (TOF) measurements, the so-called Sandwich TOF-iCT concept, which in contrast to any other iCT systems, does not require a residual energy detector for the RSP determination. Approach. A small Sandwich TOF-iCT demonstrator was built based on low gain avalanche diodes (LGADs), which are 4D-tracking detectors that allow to simultaneously measure the particle position and time-of-arrival with a precision better than 100 μm and 100 ps, respectively. Using this demonstrator, the material and energy-dependent TOF was measured for several homogeneous PMMA slabs in order to calibrate the acquired TOF against the corresponding water equivalent thickness (WET). With this calibration, two proton radiographs (pRads) of a small aluminium stair phantom were recorded at MedAustron using 83 MeV and 100.4 MeV protons. Main results. Due to the simplified WET calibration models used in this very first experimental study of this novel approach, the difference between the measured and theoretical WET ranged between 37.09% and 51.12%. Nevertheless, the first TOF-based pRad was successfully recorded showing that LGADs are suitable detector candidates for Sandwich TOF-iCT. Significance. While the system parameters and WET estimation algorithms require further optimization, this work was an important first step to realize Sandwich TOF-iCT. Due to its compact and cost-efficient design, Sandwich TOF-iCT has the potential to make iCT more feasible and attractive for clinical application, which, eventually, could enhance the treatment planning quality.

ID-Nummer: Artikel-ID: 075031
Fachbereich(e)/-gebiet(e): 05 Fachbereich Physik
05 Fachbereich Physik > Institut für Kernphysik
05 Fachbereich Physik > Institut für Kernphysik > Experimentelle Kernphysik
05 Fachbereich Physik > Institut für Kernphysik > Experimentelle Kernphysik > Untersuchung von Quark-Materie mit virtuellen Photonen
Hinterlegungsdatum: 01 Jul 2024 10:45
Letzte Änderung: 23 Jul 2024 13:36
PPN: 520095774
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