Belluati, Andrea ; Harley, Iain ; Lieberwirth, Ingo ; Bruns, Nico (2023)
An outer membrane‐inspired polymer coating protects and endows Escherichia coli with novel functionalities.
In: Small : nano micro, 19 (46)
doi: 10.1002/smll.202303384
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
A bio‐inspired membrane made of Pluronic L‐121 is produced around Escherichia coli thanks to the simple co‐extrusion of bacteria and polymer vesicles. The block copolymer‐coated bacteria can withstand various harsh shocks, for example, temperature, pressure, osmolarity, and chemical agents. The polymer membrane also makes the bacteria resistant to enzymatic digestion and enables them to degrade toxic compounds, improving their performance as whole‐cell biocatalysts. Moreover, the polymer membrane acts as an anchor layer for the surface modification of the bacteria. Being decorated with α‐amylase or lysozyme, the cells are endowed with the ability to digest starch or self‐predatory bacteria are created. Thus, without any genetic engineering, the phenotype of encapsulated bacteria is changed as they become sturdier and gain novel metabolic functionalities.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Belluati, Andrea ; Harley, Iain ; Lieberwirth, Ingo ; Bruns, Nico |
| Art des Eintrags: | Bibliographie |
| Titel: | An outer membrane‐inspired polymer coating protects and endows Escherichia coli with novel functionalities |
| Sprache: | Englisch |
| Publikationsjahr: | 15 November 2023 |
| Ort: | Weinheim |
| Verlag: | Wiley-VCH |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Small : nano micro |
| Jahrgang/Volume einer Zeitschrift: | 19 |
| (Heft-)Nummer: | 46 |
| Kollation: | 8 Seiten |
| DOI: | 10.1002/smll.202303384 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | A bio‐inspired membrane made of Pluronic L‐121 is produced around Escherichia coli thanks to the simple co‐extrusion of bacteria and polymer vesicles. The block copolymer‐coated bacteria can withstand various harsh shocks, for example, temperature, pressure, osmolarity, and chemical agents. The polymer membrane also makes the bacteria resistant to enzymatic digestion and enables them to degrade toxic compounds, improving their performance as whole‐cell biocatalysts. Moreover, the polymer membrane acts as an anchor layer for the surface modification of the bacteria. Being decorated with α‐amylase or lysozyme, the cells are endowed with the ability to digest starch or self‐predatory bacteria are created. Thus, without any genetic engineering, the phenotype of encapsulated bacteria is changed as they become sturdier and gain novel metabolic functionalities. |
| Freie Schlagworte: | block copolymers, cytoprotection, membrane functionalization, membranes, single‐cell encapsulation |
| ID-Nummer: | Artikel-ID: 2303384 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 540 Chemie 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
| Fachbereich(e)/-gebiet(e): | Interdisziplinäre Forschungsprojekte Interdisziplinäre Forschungsprojekte > Centre for Synthetic Biology 07 Fachbereich Chemie 07 Fachbereich Chemie > Ernst-Berl-Institut 07 Fachbereich Chemie > Ernst-Berl-Institut > Fachgebiet Makromolekulare Chemie |
| Hinterlegungsdatum: | 05 Jun 2024 09:27 |
| Letzte Änderung: | 05 Jun 2024 12:01 |
| PPN: | 518841243 |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
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An Outer Membrane‐Inspired Polymer Coating Protects and Endows Escherichia coli with Novel Functionalities. (deposited 04 Jun 2024 12:35)
- An outer membrane‐inspired polymer coating protects and endows Escherichia coli with novel functionalities. (deposited 05 Jun 2024 09:27) [Gegenwärtig angezeigt]
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