Schulze, Kai ; Weber, Ulrich ; Schuy, Christoph ; Durante, Marco ; Guzmán, Carlos Alberto (2024)
Influenza Virus Inactivated by Heavy Ion Beam Irradiation Stimulates Antigen-Specific Immune Responses.
In: Pharmaceutics, 2024, 16 (4)
doi: 10.26083/tuprints-00027129
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
The COVID-19 pandemic has made clear the need for effective and rapid vaccine development methods. Conventional inactivated virus vaccines, together with new technologies like vector and mRNA vaccines, were the first to be rolled out. However, the traditional methods used for virus inactivation can affect surface-exposed antigen, thereby reducing vaccine efficacy. Gamma rays have been used in the past to inactivate viruses. We recently proposed that high-energy heavy ions may be more suitable as an inactivation method because they increase the damage ratio between the viral nucleic acid and surface proteins. Here, we demonstrate that irradiation of the influenza virus using heavy ion beams constitutes a suitable method to develop effective vaccines, since immunization of mice by the intranasal route with the inactivated virus resulted in the stimulation of strong antigen-specific humoral and cellular immune responses.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2024 |
| Autor(en): | Schulze, Kai ; Weber, Ulrich ; Schuy, Christoph ; Durante, Marco ; Guzmán, Carlos Alberto |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Influenza Virus Inactivated by Heavy Ion Beam Irradiation Stimulates Antigen-Specific Immune Responses |
| Sprache: | Englisch |
| Publikationsjahr: | 14 Mai 2024 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 27 März 2024 |
| Ort der Erstveröffentlichung: | Basel |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Pharmaceutics |
| Jahrgang/Volume einer Zeitschrift: | 16 |
| (Heft-)Nummer: | 4 |
| Kollation: | 14 Seiten |
| DOI: | 10.26083/tuprints-00027129 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/27129 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | The COVID-19 pandemic has made clear the need for effective and rapid vaccine development methods. Conventional inactivated virus vaccines, together with new technologies like vector and mRNA vaccines, were the first to be rolled out. However, the traditional methods used for virus inactivation can affect surface-exposed antigen, thereby reducing vaccine efficacy. Gamma rays have been used in the past to inactivate viruses. We recently proposed that high-energy heavy ions may be more suitable as an inactivation method because they increase the damage ratio between the viral nucleic acid and surface proteins. Here, we demonstrate that irradiation of the influenza virus using heavy ion beams constitutes a suitable method to develop effective vaccines, since immunization of mice by the intranasal route with the inactivated virus resulted in the stimulation of strong antigen-specific humoral and cellular immune responses. |
| Freie Schlagworte: | influenza, vaccination, gamma rays, heavy ions |
| ID-Nummer: | Artikel-ID: 465 |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-271292 |
| Zusätzliche Informationen: | This article belongs to the Special Issue Emerging Pharmaceutical Strategies against Infectious Diseases |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) |
| Hinterlegungsdatum: | 14 Mai 2024 14:00 |
| Letzte Änderung: | 16 Mai 2024 15:27 |
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| Suche nach Titel in: | TUfind oder in Google |
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- Influenza Virus Inactivated by Heavy Ion Beam Irradiation Stimulates Antigen-Specific Immune Responses. (deposited 14 Mai 2024 14:00) [Gegenwärtig angezeigt]
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