Bagherabadi, Mohadeseh ; Andrieu-Brunsen, Annette (2024)
Ultrashort Peptide Grafting on Mesoporous Films and Its Impact on Ionic Mesopore Accessibility.
In: Langmuir, 40 (8)
doi: 10.1021/acs.langmuir.3c03361
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
An approach for direct in-pore solid-phase ultrashort peptide synthesis on mesoporous films using the amino acids arginine, leucine, and glycine is presented. Although the number of grafted amino acids remains low, the ionic mesopore accessibility can be gradually adjusted. The addition of arginine in up to five reaction cycles leads to a progressive increase in positive mesopore charge density, which gradually increases the anionic mesopore accessibility at acidic pH. At basic pH, the remaining silanol groups at the pore wall still dominate counter-charged cation mesopore accessibility. Thus, specific peptide sequence design is demonstrated to be a sensitive tool for molecular transport control in nanoscale pores. Overall, the direct in-pore solid-phase ultrashort peptide synthesis on mesoporous films using the sequences of different amino acids opens up exciting opportunities for the development of innovative materials with precisely tailored properties and functions based on specific peptide sequence design.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2024 |
| Autor(en): | Bagherabadi, Mohadeseh ; Andrieu-Brunsen, Annette |
| Art des Eintrags: | Bibliographie |
| Titel: | Ultrashort Peptide Grafting on Mesoporous Films and Its Impact on Ionic Mesopore Accessibility |
| Sprache: | Englisch |
| Publikationsjahr: | 12 Februar 2024 |
| Ort: | Darmstadt |
| Verlag: | ACS |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Langmuir |
| Jahrgang/Volume einer Zeitschrift: | 40 |
| (Heft-)Nummer: | 8 |
| Kollation: | 28 Seiten |
| DOI: | 10.1021/acs.langmuir.3c03361 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | An approach for direct in-pore solid-phase ultrashort peptide synthesis on mesoporous films using the amino acids arginine, leucine, and glycine is presented. Although the number of grafted amino acids remains low, the ionic mesopore accessibility can be gradually adjusted. The addition of arginine in up to five reaction cycles leads to a progressive increase in positive mesopore charge density, which gradually increases the anionic mesopore accessibility at acidic pH. At basic pH, the remaining silanol groups at the pore wall still dominate counter-charged cation mesopore accessibility. Thus, specific peptide sequence design is demonstrated to be a sensitive tool for molecular transport control in nanoscale pores. Overall, the direct in-pore solid-phase ultrashort peptide synthesis on mesoporous films using the sequences of different amino acids opens up exciting opportunities for the development of innovative materials with precisely tailored properties and functions based on specific peptide sequence design. |
| Freie Schlagworte: | short peptide, ion transport, solid-phase peptide synthesis, biofunctionalization, BODIPY, mesoporous silica, nanopores |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Ernst-Berl-Institut 07 Fachbereich Chemie > Ernst-Berl-Institut > Fachgebiet Makromolekulare Chemie |
| Hinterlegungsdatum: | 02 Mai 2024 07:34 |
| Letzte Änderung: | 02 Mai 2024 07:34 |
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Verfügbare Versionen dieses Eintrags
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Ultrashort Peptide Grafting on Mesoporous Films and Its Impact on Ionic Mesopore Accessibility. (deposited 30 Apr 2024 12:35)
- Ultrashort Peptide Grafting on Mesoporous Films and Its Impact on Ionic Mesopore Accessibility. (deposited 02 Mai 2024 07:34) [Gegenwärtig angezeigt]
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