Friedrich, Thomas ; Henthorn, Nicholas ; Durante, Marco (2021)
Modeling Radioimmune Response - Current Status and Perspectives.
In: Frontiers in Oncology, 11
doi: 10.3389/fonc.2021.647272
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
The combination of immune therapy with radiation offers an exciting and promising treatment modality in cancer therapy. It has been hypothesized that radiation induces damage signals within the tumor, making it more detectable for the immune system. In combination with inhibiting immune checkpoints an effective anti-tumor immune response may be established. This inversion from tumor immune evasion raises numerous questions to be solved to support an effective clinical implementation: These include the optimum immune drug and radiation dose time courses, the amount of damage and associated doses required to stimulate an immune response, and the impact of lymphocyte status and dynamics. Biophysical modeling can offer unique insights, providing quantitative information addressing these factors and highlighting mechanisms of action. In this work we review the existing modeling approaches of combined 'radioimmune' response, as well as associated fields of study. We propose modeling attempts that appear relevant for an effective and predictive model. We emphasize the importance of the time course of drug and dose delivery in view to the time course of the triggered biological processes. Special attention is also paid to the dose distribution to circulating blood lymphocytes and the effect this has on immune competence.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2021 |
| Autor(en): | Friedrich, Thomas ; Henthorn, Nicholas ; Durante, Marco |
| Art des Eintrags: | Bibliographie |
| Titel: | Modeling Radioimmune Response - Current Status and Perspectives |
| Sprache: | Englisch |
| Publikationsjahr: | 16 März 2021 |
| Ort: | Lausanne |
| Verlag: | Frontiers Media S.A. |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in Oncology |
| Jahrgang/Volume einer Zeitschrift: | 11 |
| Kollation: | 11 Seiten |
| DOI: | 10.3389/fonc.2021.647272 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | The combination of immune therapy with radiation offers an exciting and promising treatment modality in cancer therapy. It has been hypothesized that radiation induces damage signals within the tumor, making it more detectable for the immune system. In combination with inhibiting immune checkpoints an effective anti-tumor immune response may be established. This inversion from tumor immune evasion raises numerous questions to be solved to support an effective clinical implementation: These include the optimum immune drug and radiation dose time courses, the amount of damage and associated doses required to stimulate an immune response, and the impact of lymphocyte status and dynamics. Biophysical modeling can offer unique insights, providing quantitative information addressing these factors and highlighting mechanisms of action. In this work we review the existing modeling approaches of combined 'radioimmune' response, as well as associated fields of study. We propose modeling attempts that appear relevant for an effective and predictive model. We emphasize the importance of the time course of drug and dose delivery in view to the time course of the triggered biological processes. Special attention is also paid to the dose distribution to circulating blood lymphocytes and the effect this has on immune competence. |
| Freie Schlagworte: | radiation immunity, immunotherapy, radiation therapy, modeling, radiation effect |
| ID-Nummer: | Artikel-ID: 647272 |
| Zusätzliche Informationen: | Erstveröffentlichung; This article is part of the Research Topic: Radiochemotherapy in Multimodal Cancer Therapy Specialty section: This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Oncology |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) |
| Hinterlegungsdatum: | 14 Mär 2024 14:20 |
| Letzte Änderung: | 14 Mär 2024 14:20 |
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| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
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Modeling Radioimmune Response - Current Status and Perspectives. (deposited 12 Mär 2024 13:20)
- Modeling Radioimmune Response - Current Status and Perspectives. (deposited 14 Mär 2024 14:20) [Gegenwärtig angezeigt]
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