Horst, Felix ; Schardt, Dieter ; Iwase, Hiroshi ; Schuy, Christoph ; Durante, Marco ; Weber, Uli (2024)
Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He.
In: Physics in Medicine & Biology, 2021, 66 (9)
doi: 10.26083/tuprints-00020501
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
There is increasing interest in using helium ions for radiotherapy, complementary to protons and carbon ions. A large number of patients were treated with ⁴He ions in the US heavy ion therapy project and novel ⁴He ion treatment programs are under preparation, for instance in Germany and Japan. ³He ions have been proposed as an alternative to ⁴He ions because the acceleration of ³He is technically less difficult than ⁴He. In particular, beam contaminations have been pointed out as a potential safety issue for ⁴He ion beams. This motivated a series of experiments with ³He ion beams at Gesellschaft für Schwerionenforschung (GSI), Darmstadt. Measured ³He Bragg curves and fragmentation data in water are presented in this work. Those experimental data are compared with FLUKA Monte Carlo simulations. The physical characteristics of ³He ion beams are compared to those of ⁴He, for which a large set of data became available in recent years from the preparation work at the Heidelberger Ionenstrahl-Therapiezentrum (HIT). The dose distributions (spread out Bragg peaks, lateral profiles) that can be achieved with ³He ions are found to be competitive to ⁴He dose distributions. The effect of beam contaminations on ⁴He depth dose distribution is also addressed. It is concluded that ³He ions can be a viable alternative to ⁴He, especially for future compact therapy accelerator designs and upgrades of existing ion therapy facilities.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2024 |
| Autor(en): | Horst, Felix ; Schardt, Dieter ; Iwase, Hiroshi ; Schuy, Christoph ; Durante, Marco ; Weber, Uli |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He |
| Sprache: | Englisch |
| Publikationsjahr: | 5 März 2024 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2021 |
| Ort der Erstveröffentlichung: | Bristol |
| Verlag: | IOP Publishing |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Physics in Medicine & Biology |
| Jahrgang/Volume einer Zeitschrift: | 66 |
| (Heft-)Nummer: | 9 |
| Kollation: | 16 Seiten |
| DOI: | 10.26083/tuprints-00020501 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/20501 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | There is increasing interest in using helium ions for radiotherapy, complementary to protons and carbon ions. A large number of patients were treated with ⁴He ions in the US heavy ion therapy project and novel ⁴He ion treatment programs are under preparation, for instance in Germany and Japan. ³He ions have been proposed as an alternative to ⁴He ions because the acceleration of ³He is technically less difficult than ⁴He. In particular, beam contaminations have been pointed out as a potential safety issue for ⁴He ion beams. This motivated a series of experiments with ³He ion beams at Gesellschaft für Schwerionenforschung (GSI), Darmstadt. Measured ³He Bragg curves and fragmentation data in water are presented in this work. Those experimental data are compared with FLUKA Monte Carlo simulations. The physical characteristics of ³He ion beams are compared to those of ⁴He, for which a large set of data became available in recent years from the preparation work at the Heidelberger Ionenstrahl-Therapiezentrum (HIT). The dose distributions (spread out Bragg peaks, lateral profiles) that can be achieved with ³He ions are found to be competitive to ⁴He dose distributions. The effect of beam contaminations on ⁴He depth dose distribution is also addressed. It is concluded that ³He ions can be a viable alternative to ⁴He, especially for future compact therapy accelerator designs and upgrades of existing ion therapy facilities. |
| Freie Schlagworte: | helium ion therapy, particle therapy, Bragg curve, nuclear fragmentation, heavy ion therapy, Monte Carlo simulation |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-205018 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) |
| Hinterlegungsdatum: | 05 Mär 2024 12:55 |
| Letzte Änderung: | 07 Mär 2024 10:31 |
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- Physical characterization of ³He ion beams for radiotherapy and comparison with ⁴He. (deposited 05 Mär 2024 12:55) [Gegenwärtig angezeigt]
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