Sokol, Olga ; Durante, Marco (2023)
Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them?
In: Cancers, 15 (18)
doi: 10.3390/cancers15184494
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
Hypoxia, which is associated with abnormal vessel growth, is a characteristic feature of many solid tumors that increases their metastatic potential and resistance to radiotherapy. Carbon-ion radiation therapy, either alone or in combination with other treatments, is one of the most promising treatments for hypoxic tumors because the oxygen enhancement ratio decreases with increasing particle LET. Nevertheless, current clinical practice does not yet fully benefit from the use of carbon ions to tackle hypoxia. Here, we provide an overview of the existing experimental and clinical evidence supporting the efficacy of C-ion radiotherapy in overcoming hypoxia-induced radioresistance, followed by a discussion of the strategies proposed to enhance it, including different approaches to maximize LET in the tumors.
| Typ des Eintrags: | Artikel | ||||
|---|---|---|---|---|---|
| Erschienen: | 2023 | ||||
| Autor(en): | Sokol, Olga ; Durante, Marco | ||||
| Art des Eintrags: | Bibliographie | ||||
| Titel: | Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them? | ||||
| Sprache: | Englisch | ||||
| Publikationsjahr: | 9 September 2023 | ||||
| Verlag: | MDPI | ||||
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Cancers | ||||
| Jahrgang/Volume einer Zeitschrift: | 15 | ||||
| (Heft-)Nummer: | 18 | ||||
| Kollation: | 18 Seiten | ||||
| DOI: | 10.3390/cancers15184494 | ||||
| Zugehörige Links: | |||||
| Kurzbeschreibung (Abstract): | Hypoxia, which is associated with abnormal vessel growth, is a characteristic feature of many solid tumors that increases their metastatic potential and resistance to radiotherapy. Carbon-ion radiation therapy, either alone or in combination with other treatments, is one of the most promising treatments for hypoxic tumors because the oxygen enhancement ratio decreases with increasing particle LET. Nevertheless, current clinical practice does not yet fully benefit from the use of carbon ions to tackle hypoxia. Here, we provide an overview of the existing experimental and clinical evidence supporting the efficacy of C-ion radiotherapy in overcoming hypoxia-induced radioresistance, followed by a discussion of the strategies proposed to enhance it, including different approaches to maximize LET in the tumors. |
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| Freie Schlagworte: | hypoxia, carbon ions, CIRT, LET painting, particle therapy, radiotherapy | ||||
| Zusätzliche Informationen: | This article belongs to the Special Issue Carbon Ion Radiotherapy; Erstveröffentlichung; Art.No.: 4494 |
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| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit |
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| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) > Biophysik |
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| Hinterlegungsdatum: | 05 Mär 2024 11:42 | ||||
| Letzte Änderung: | 05 Mär 2024 11:42 | ||||
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| Suche nach Titel in: | TUfind oder in Google | ||||
Verfügbare Versionen dieses Eintrags
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Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them? (deposited 19 Jan 2024 13:57)
- Carbon Ions for Hypoxic Tumors: Are We Making the Most of Them? (deposited 05 Mär 2024 11:42) [Gegenwärtig angezeigt]
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