Wang, Yingqian ; Zhang, Siyun ; Yan, Hewei ; Quan, Jiaxin ; Yang, Lei ; Chen, Xue ; Toimil-Molares, Maria Eugenia ; Trautmann, Christina ; Li, Haibing (2021)
Efficient chiral nanosenor based on tip-modified nanochannels.
In: Analytical Chemistry, 93 (15)
doi: 10.1021/acs.analchem.0c05390
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Enantiomers of various drug molecules have a specific effect on living organisms. Accordingly, developing a sample method for the efficient and rapid recognition of chiral drug enantiomers is of great industrial value and physiological significance. Here, inspired by the structure of ion channels in living organisms, we developed a chiral nanosensor based on an artificial tip-modified nanochannel system that allows efficient selective recognition of chiral drugs. In this system, l-alanine-pillar[5]arenes as selective receptors were introduced on the tip side of conical nanochannels to form an enantioselective “gate”. The selective coefficient of our system toward R-propranolol is 4.96, which is higher than the traditional fully modified nanochannels in this work.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2021 |
| Autor(en): | Wang, Yingqian ; Zhang, Siyun ; Yan, Hewei ; Quan, Jiaxin ; Yang, Lei ; Chen, Xue ; Toimil-Molares, Maria Eugenia ; Trautmann, Christina ; Li, Haibing |
| Art des Eintrags: | Bibliographie |
| Titel: | Efficient chiral nanosenor based on tip-modified nanochannels |
| Sprache: | Englisch |
| Publikationsjahr: | 7 April 2021 |
| Verlag: | ACS Publications |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Analytical Chemistry |
| Jahrgang/Volume einer Zeitschrift: | 93 |
| (Heft-)Nummer: | 15 |
| DOI: | 10.1021/acs.analchem.0c05390 |
| Kurzbeschreibung (Abstract): | Enantiomers of various drug molecules have a specific effect on living organisms. Accordingly, developing a sample method for the efficient and rapid recognition of chiral drug enantiomers is of great industrial value and physiological significance. Here, inspired by the structure of ion channels in living organisms, we developed a chiral nanosensor based on an artificial tip-modified nanochannel system that allows efficient selective recognition of chiral drugs. In this system, l-alanine-pillar[5]arenes as selective receptors were introduced on the tip side of conical nanochannels to form an enantioselective “gate”. The selective coefficient of our system toward R-propranolol is 4.96, which is higher than the traditional fully modified nanochannels in this work. |
| Freie Schlagworte: | electrical properties, functionalization, membranes, modification, nanochannels |
| Fachbereich(e)/-gebiet(e): | 11 Fachbereich Material- und Geowissenschaften 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft > Fachgebiet Ionenstrahlmodifizierte Materialien |
| Hinterlegungsdatum: | 27 Feb 2024 07:18 |
| Letzte Änderung: | 27 Feb 2024 07:18 |
| PPN: | |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
 |
Frage zum Eintrag |
Optionen (nur für Redakteure)
 |
Redaktionelle Details anzeigen |
Drucken
Impressum