Toum Terrones, Yamili ; Laucirica, Gregorio ; Cayón, Vanina M. ; Fenoy, Gonzalo E. ; Cortez, M. Lorena ; Toimil-Molares, María Eugenia ; Trautmann, Christina ; Mamisollé, Waldemar A. ; Azzaroni, Omar (2022)
Highly sensitive acetylcholine biosensing via chemical amplification of enzymatic processes in nanochannels.
In: Chemical Communications, 58 (73)
doi: 10.1039/d2cc02249d
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Acetylcholinesterase-modified nanochannels are proposed as reliable and reproducible nanofluidic sensors for highly sensitive detection of acetylcholine. The operation mechanism relies on the use of weak polyelectrolytes as "chemical amplifiers" that adjust/reconfigure the nanochannel surface charge in the presence of local pH changes induced by the enzymatic reaction. Experimental results show that the presence of acetylcholine can be transduced into measurable ionic signals with a low limit of detection.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Toum Terrones, Yamili ; Laucirica, Gregorio ; Cayón, Vanina M. ; Fenoy, Gonzalo E. ; Cortez, M. Lorena ; Toimil-Molares, María Eugenia ; Trautmann, Christina ; Mamisollé, Waldemar A. ; Azzaroni, Omar |
| Art des Eintrags: | Bibliographie |
| Titel: | Highly sensitive acetylcholine biosensing via chemical amplification of enzymatic processes in nanochannels |
| Sprache: | Englisch |
| Publikationsjahr: | 11 August 2022 |
| Verlag: | Royal Society of Chemistry (RSC) |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Chemical Communications |
| Jahrgang/Volume einer Zeitschrift: | 58 |
| (Heft-)Nummer: | 73 |
| DOI: | 10.1039/d2cc02249d |
| Kurzbeschreibung (Abstract): | Acetylcholinesterase-modified nanochannels are proposed as reliable and reproducible nanofluidic sensors for highly sensitive detection of acetylcholine. The operation mechanism relies on the use of weak polyelectrolytes as "chemical amplifiers" that adjust/reconfigure the nanochannel surface charge in the presence of local pH changes induced by the enzymatic reaction. Experimental results show that the presence of acetylcholine can be transduced into measurable ionic signals with a low limit of detection. |
| Fachbereich(e)/-gebiet(e): | 11 Fachbereich Material- und Geowissenschaften 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft > Fachgebiet Ionenstrahlmodifizierte Materialien |
| Hinterlegungsdatum: | 26 Feb 2024 08:22 |
| Letzte Änderung: | 26 Feb 2024 13:34 |
| PPN: | 515817279 |
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