Hanitsch, Leif ; Baumann, Ulrich ; Boztug, Kaan ; Burkhard‐Meier, Ulrike ; Fasshauer, Maria ; Habermehl, Pirmin ; Hauck, Fabian ; Klock, Gerd ; Liese, Johannes ; Meyer, Oliver ; Müller, Rainer ; Pachlopnik‐Schmid, Jana ; Pfeiffer‐Kascha, Dorothea ; Warnatz, Klaus ; Wehr, Claudia ; Wittke, Kirsten ; Niehues, Tim ; Bernuth, Horst von (2024)
Treatment and management of primary antibody deficiency: German interdisciplinary evidence‐based consensus guideline.
In: European Journal of Immunology : Basic, Clinical, Translational, 2020, 50 (10)
doi: 10.26083/tuprints-00017813
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
This evidence‐based clinical guideline provides consensus‐recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. Recommendations were based on results of a systematic literature search, data extraction, and evaluation of methodology and study quality in combination with the clinical expertise of the respective representatives. Consensus‐based recommendations were determined via nominal group technique. PADs are the largest clinically relevant group of primary immunodeficiencies. Most patients with PADs present with increased susceptibility to infections, however immune dysregulation, autoimmunity, and cancer affect a significant number of patients and may precede infections. This guideline therefore covers interdisciplinary clinical and therapeutic aspects of infectious (e.g., antibiotic prophylaxis, management of bronchiectasis) and non‐infectious manifestations (e.g., management of granulomatous disease, immune cytopenia). PADs are grouped into disease entities with definitive, probable, possible, or unlikely benefit of IgG‐replacement therapy. Summary and consensus‐recommendations are provided for treatment indication, dosing, routes of administration, and adverse events of IgG‐replacement therapy. Special aspects of concomitant impaired T‐cell function are highlighted as well as clinical data on selected monogenetic inborn errors of immunity formerly classified into PADs (APDS, CTLA‐4‐, and LRBA‐deficiency).
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2024 |
| Autor(en): | Hanitsch, Leif ; Baumann, Ulrich ; Boztug, Kaan ; Burkhard‐Meier, Ulrike ; Fasshauer, Maria ; Habermehl, Pirmin ; Hauck, Fabian ; Klock, Gerd ; Liese, Johannes ; Meyer, Oliver ; Müller, Rainer ; Pachlopnik‐Schmid, Jana ; Pfeiffer‐Kascha, Dorothea ; Warnatz, Klaus ; Wehr, Claudia ; Wittke, Kirsten ; Niehues, Tim ; Bernuth, Horst von |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Treatment and management of primary antibody deficiency: German interdisciplinary evidence‐based consensus guideline |
| Sprache: | Englisch |
| Publikationsjahr: | 12 Februar 2024 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2020 |
| Ort der Erstveröffentlichung: | Weinheim |
| Verlag: | Wiley-VCH |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | European Journal of Immunology : Basic, Clinical, Translational |
| Jahrgang/Volume einer Zeitschrift: | 50 |
| (Heft-)Nummer: | 10 |
| DOI: | 10.26083/tuprints-00017813 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/17813 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | This evidence‐based clinical guideline provides consensus‐recommendations for the treatment and care of patients with primary antibody deficiencies (PADs). The guideline group comprised 20 clinical and scientific expert associations of the German, Swiss, and Austrian healthcare system and representatives of patients. Recommendations were based on results of a systematic literature search, data extraction, and evaluation of methodology and study quality in combination with the clinical expertise of the respective representatives. Consensus‐based recommendations were determined via nominal group technique. PADs are the largest clinically relevant group of primary immunodeficiencies. Most patients with PADs present with increased susceptibility to infections, however immune dysregulation, autoimmunity, and cancer affect a significant number of patients and may precede infections. This guideline therefore covers interdisciplinary clinical and therapeutic aspects of infectious (e.g., antibiotic prophylaxis, management of bronchiectasis) and non‐infectious manifestations (e.g., management of granulomatous disease, immune cytopenia). PADs are grouped into disease entities with definitive, probable, possible, or unlikely benefit of IgG‐replacement therapy. Summary and consensus‐recommendations are provided for treatment indication, dosing, routes of administration, and adverse events of IgG‐replacement therapy. Special aspects of concomitant impaired T‐cell function are highlighted as well as clinical data on selected monogenetic inborn errors of immunity formerly classified into PADs (APDS, CTLA‐4‐, and LRBA‐deficiency). |
| Freie Schlagworte: | autoimmunity, CVID, hypogammaglobulinemia, immunoglobulins, primary antibody deficiency |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-178138 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Clemens-Schöpf-Institut |
| Hinterlegungsdatum: | 12 Feb 2024 13:57 |
| Letzte Änderung: | 13 Feb 2024 07:45 |
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| Zugehörige Links: | |
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| Suche nach Titel in: | TUfind oder in Google |
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- Treatment and management of primary antibody deficiency: German interdisciplinary evidence‐based consensus guideline. (deposited 12 Feb 2024 13:57) [Gegenwärtig angezeigt]
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