Geisler, Ramsia ; Dargel, Carina ; Hellweg, Thomas (2024)
The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers.
In: Molecules, 2019, 25 (1)
doi: 10.26083/tuprints-00016104
Artikel, Zweitveröffentlichung, Verlagsversion
 | Es ist eine neuere Version dieses Eintrags verfügbar. |
Kurzbeschreibung (Abstract)
This review discusses recent progress in physicochemical understanding of the action of the saponin β-aescin (also called β-escin), the biologically active component in the seeds of the horse chestnut tree Aesculus hippocastanum. β-Aescin is used in pharmacological and cosmetic applications showing strong surface activity. In this review, we outline the most important findings describing the behavior of β-aescin in solution (e.g., critical micelle concentration (cmc) and micelle shape) and special physicochemical properties of adsorbed β-aescin monolayers at the air–water and oil–water interface. Such monolayers were found to posses very special viscoelastic properties. The presentation of the experimental findings is complemented by discussing recent molecular dynamics simulations. These simulations do not only quantify the predominant interactions in adsorbed monolayers but also highlight the different behavior of neutral and ionized β-aescin molecules. The review concludes on the interaction of β-aescin with phospholipid model membranes in the form of bilayers and Langmuir monolayers. The interaction of β-aescin with lipid bilayers was found to strongly depend on its cmc. At concentrations below the cmc, membrane parameters are modified whereas above the cmc, complete solubilization of the bilayers occurs, depending on lipid phase state and concentration. In the presence of gel-phase phospholipids, discoidal bicelles form; these are tunable in size by composition. The phase behavior of β-aescin with lipid membranes can also be modified by addition of other molecules such as cholesterol or drug molecules. The lipid phase state also determines the penetration rate of β-aescin molecules into lipid monolayers. The strongest interaction was always found in the presence of gel-phase phospholipid molecules.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2024 |
| Autor(en): | Geisler, Ramsia ; Dargel, Carina ; Hellweg, Thomas |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers |
| Sprache: | Englisch |
| Publikationsjahr: | 16 Januar 2024 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2019 |
| Ort der Erstveröffentlichung: | Basel |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Molecules |
| Jahrgang/Volume einer Zeitschrift: | 25 |
| (Heft-)Nummer: | 1 |
| Kollation: | 22 Seiten |
| DOI: | 10.26083/tuprints-00016104 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/16104 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | This review discusses recent progress in physicochemical understanding of the action of the saponin β-aescin (also called β-escin), the biologically active component in the seeds of the horse chestnut tree Aesculus hippocastanum. β-Aescin is used in pharmacological and cosmetic applications showing strong surface activity. In this review, we outline the most important findings describing the behavior of β-aescin in solution (e.g., critical micelle concentration (cmc) and micelle shape) and special physicochemical properties of adsorbed β-aescin monolayers at the air–water and oil–water interface. Such monolayers were found to posses very special viscoelastic properties. The presentation of the experimental findings is complemented by discussing recent molecular dynamics simulations. These simulations do not only quantify the predominant interactions in adsorbed monolayers but also highlight the different behavior of neutral and ionized β-aescin molecules. The review concludes on the interaction of β-aescin with phospholipid model membranes in the form of bilayers and Langmuir monolayers. The interaction of β-aescin with lipid bilayers was found to strongly depend on its cmc. At concentrations below the cmc, membrane parameters are modified whereas above the cmc, complete solubilization of the bilayers occurs, depending on lipid phase state and concentration. In the presence of gel-phase phospholipids, discoidal bicelles form; these are tunable in size by composition. The phase behavior of β-aescin with lipid membranes can also be modified by addition of other molecules such as cholesterol or drug molecules. The lipid phase state also determines the penetration rate of β-aescin molecules into lipid monolayers. The strongest interaction was always found in the presence of gel-phase phospholipid molecules. |
| Freie Schlagworte: | saponin, β-aescin, β-escin, lipid membrane, Langmuir monolayers, air–water interface, MD simulation, critical micelle concentration cmc, Aesculus hippocastanum |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-161040 |
| Zusätzliche Informationen: | This article belongs to the Special Issue Saponins |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) > Soft Matter at Interfaces (SMI) |
| Hinterlegungsdatum: | 16 Jan 2024 12:29 |
| Letzte Änderung: | 18 Jan 2024 12:08 |
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| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
- The Biosurfactant β-Aescin: A Review on the Physico-Chemical Properties and Its Interaction with Lipid Model Membranes and Langmuir Monolayers. (deposited 16 Jan 2024 12:29) [Gegenwärtig angezeigt]
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