Tinganelli, Walter ; Hitrec, Timna ; Romani, Fabrizio ; Simoniello, Palma ; Squarcio, Fabio ; Stanzani, Agnese ; Piscitiello, Emiliana ; Marchesano, Valentina ; Luppi, Marco ; Sioli, Maximiliano ; Helm, Alexander ; Compagnone, Gaetano ; Morganti, Alessio G. ; Amici, Roberto ; Negrini, Matteo ; Zoccoli, Antonio ; Durante, Marco ; Cerri, Matteo (2024)
Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor.
In: International Journal of Molecular Sciences, 2019, 20 (2)
doi: 10.26083/tuprints-00022276
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
Hibernation has been proposed as a tool for human space travel. In recent years, a procedure to induce a metabolic state known as "synthetic torpor" in non-hibernating mammals was successfully developed. Synthetic torpor may not only be an efficient method to spare resources and reduce psychological problems in long-term exploratory-class missions, but may also represent a countermeasure against cosmic rays. Here we show the preliminary results from an experiment in rats exposed to ionizing radiation in normothermic conditions or synthetic torpor. Animals were irradiated with 3 Gy X-rays and organs were collected 4 h after exposure. Histological analysis of liver and testicle showed a reduced toxicity in animals irradiated in torpor compared to controls irradiated at normal temperature and metabolic activity. The expression of ataxia telangiectasia mutated (ATM) in the liver was significantly downregulated in the group of animal in synthetic torpor. In the testicle, more genes involved in the DNA damage signaling were downregulated during synthetic torpor. These data show for the first time that synthetic torpor is a radioprotector in non-hibernators, similarly to natural torpor in hibernating animals. Synthetic torpor can be an effective strategy to protect humans during long term space exploration of the solar system.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2024 |
| Autor(en): | Tinganelli, Walter ; Hitrec, Timna ; Romani, Fabrizio ; Simoniello, Palma ; Squarcio, Fabio ; Stanzani, Agnese ; Piscitiello, Emiliana ; Marchesano, Valentina ; Luppi, Marco ; Sioli, Maximiliano ; Helm, Alexander ; Compagnone, Gaetano ; Morganti, Alessio G. ; Amici, Roberto ; Negrini, Matteo ; Zoccoli, Antonio ; Durante, Marco ; Cerri, Matteo |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor |
| Sprache: | Englisch |
| Publikationsjahr: | 12 Januar 2024 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2019 |
| Ort der Erstveröffentlichung: | Basel |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | International Journal of Molecular Sciences |
| Jahrgang/Volume einer Zeitschrift: | 20 |
| (Heft-)Nummer: | 2 |
| Kollation: | 12 Seiten |
| DOI: | 10.26083/tuprints-00022276 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/22276 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | Hibernation has been proposed as a tool for human space travel. In recent years, a procedure to induce a metabolic state known as "synthetic torpor" in non-hibernating mammals was successfully developed. Synthetic torpor may not only be an efficient method to spare resources and reduce psychological problems in long-term exploratory-class missions, but may also represent a countermeasure against cosmic rays. Here we show the preliminary results from an experiment in rats exposed to ionizing radiation in normothermic conditions or synthetic torpor. Animals were irradiated with 3 Gy X-rays and organs were collected 4 h after exposure. Histological analysis of liver and testicle showed a reduced toxicity in animals irradiated in torpor compared to controls irradiated at normal temperature and metabolic activity. The expression of ataxia telangiectasia mutated (ATM) in the liver was significantly downregulated in the group of animal in synthetic torpor. In the testicle, more genes involved in the DNA damage signaling were downregulated during synthetic torpor. These data show for the first time that synthetic torpor is a radioprotector in non-hibernators, similarly to natural torpor in hibernating animals. Synthetic torpor can be an effective strategy to protect humans during long term space exploration of the solar system. |
| Freie Schlagworte: | radiation, liver, testicle, synthetic torpor, torpor, hypothermia, hibernation, raphe pallidus, ATM, space exploration |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-222766 |
| Zusätzliche Informationen: | This article belongs to the Special Issue Adaptation of Living Organisms in Space: From Mammals to Plants |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) |
| Hinterlegungsdatum: | 12 Jan 2024 13:42 |
| Letzte Änderung: | 18 Jan 2024 12:07 |
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Verfügbare Versionen dieses Eintrags
- Hibernation and Radioprotection: Gene Expression in the Liver and Testicle of Rats Irradiated under Synthetic Torpor. (deposited 12 Jan 2024 13:42) [Gegenwärtig angezeigt]
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