Bolze, Holger ; Riewe, Juliane ; Bunjes, Heike ; Dietzel, Andreas ; Burg, Thomas P. (2023)
Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications.
In: Chemical Engineering & Technology, 2021, 44 (3)
doi: 10.26083/tuprints-00017826
Artikel, Zweitveröffentlichung, Verlagsversion
 | Es ist eine neuere Version dieses Eintrags verfügbar. |
Kurzbeschreibung (Abstract)
Microfluidic processes are of great interest for the production of nanoparticles with reproducible properties. However, in real systems, it is difficult to completely exclude incidental production of larger particles, which can contaminate the product or clog downstream process modules. A class of microfluidic filters was devised for eliminating particulate contamination in multistage continuous‐flow processes. To achieve high throughput and filtration efficiency, a high‐surface‐area filter with an application‐adapted bonding method was developed. As a model application, the filtration efficiency was analyzed for lipid nanoparticles made by microfluidic antisolvent precipitation and the results were compared with requirements of the European and US guidelines.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Bolze, Holger ; Riewe, Juliane ; Bunjes, Heike ; Dietzel, Andreas ; Burg, Thomas P. |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications |
| Sprache: | Englisch |
| Publikationsjahr: | 22 Dezember 2023 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2021 |
| Ort der Erstveröffentlichung: | Weinheim |
| Verlag: | Wiley-VCH |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Chemical Engineering & Technology |
| Jahrgang/Volume einer Zeitschrift: | 44 |
| (Heft-)Nummer: | 3 |
| DOI: | 10.26083/tuprints-00017826 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/17826 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | Microfluidic processes are of great interest for the production of nanoparticles with reproducible properties. However, in real systems, it is difficult to completely exclude incidental production of larger particles, which can contaminate the product or clog downstream process modules. A class of microfluidic filters was devised for eliminating particulate contamination in multistage continuous‐flow processes. To achieve high throughput and filtration efficiency, a high‐surface‐area filter with an application‐adapted bonding method was developed. As a model application, the filtration efficiency was analyzed for lipid nanoparticles made by microfluidic antisolvent precipitation and the results were compared with requirements of the European and US guidelines. |
| Freie Schlagworte: | In‐line filtration, Lipid nanoparticles, Membrane filtration, Nanoparticle synthesis, Precipitation |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-178263 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 600 Technik, Medizin, angewandte Wissenschaften > 660 Technische Chemie |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Integrierte Mikro-Nano-Systeme |
| Hinterlegungsdatum: | 22 Dez 2023 13:42 |
| Letzte Änderung: | 03 Jan 2024 10:25 |
| PPN: | |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
- Protective Filtration for Microfluidic Nanoparticle Precipitation for Pharmaceutical Applications. (deposited 22 Dez 2023 13:42) [Gegenwärtig angezeigt]
 |
Frage zum Eintrag |
Optionen (nur für Redakteure)
 |
Redaktionelle Details anzeigen |
Drucken
Impressum