Kav, Batuhan ; Demé, Bruno ; Gege, Christian ; Tanaka, Motomu ; Schneck, Emanuel ; Weikl, Thomas R. (2023)
Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion.
In: Frontiers in Molecular Biosciences, 2021, 8
doi: 10.26083/tuprints-00020087
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
Glycolipids mediate stable membrane adhesion of potential biological relevance. In this article, we investigate the trans- and cis-interactions of glycolipids in molecular dynamics simulations and relate these interactions to the glycolipid-induced average separations of membranes obtained from neutron scattering experiments. We find that the cis-interactions between glycolipids in the same membrane leaflet tend to strengthen the trans-interactions between glycolipids in apposing leaflets. The trans-interactions of the glycolipids in our simulations require local membrane separations that are significantly smaller than the average membrane separations in the neutron scattering experiments, which indicates an important role of membrane shape fluctuations in glycolipid trans-binding. Simulations at the experimentally measured average membrane separations provide a molecular picture of the interplay between glycolipid attraction and steric repulsion of the fluctuating membranes probed in the experiments.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Kav, Batuhan ; Demé, Bruno ; Gege, Christian ; Tanaka, Motomu ; Schneck, Emanuel ; Weikl, Thomas R. |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Interplay of Trans- and Cis-Interactions of Glycolipids in Membrane Adhesion |
| Sprache: | Englisch |
| Publikationsjahr: | 14 November 2023 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2021 |
| Ort der Erstveröffentlichung: | Lausanne |
| Verlag: | Frontiers Media S.A. |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in Molecular Biosciences |
| Jahrgang/Volume einer Zeitschrift: | 8 |
| Kollation: | 13 Seiten |
| DOI: | 10.26083/tuprints-00020087 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/20087 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | Glycolipids mediate stable membrane adhesion of potential biological relevance. In this article, we investigate the trans- and cis-interactions of glycolipids in molecular dynamics simulations and relate these interactions to the glycolipid-induced average separations of membranes obtained from neutron scattering experiments. We find that the cis-interactions between glycolipids in the same membrane leaflet tend to strengthen the trans-interactions between glycolipids in apposing leaflets. The trans-interactions of the glycolipids in our simulations require local membrane separations that are significantly smaller than the average membrane separations in the neutron scattering experiments, which indicates an important role of membrane shape fluctuations in glycolipid trans-binding. Simulations at the experimentally measured average membrane separations provide a molecular picture of the interplay between glycolipid attraction and steric repulsion of the fluctuating membranes probed in the experiments. |
| Freie Schlagworte: | glycolipids, carbohydrate–carbohydrate interactions, LewisX carbohydrate, membrane adhesion, membrane shape fluctuations, molecular dynamics (MD) simulations, neutron scattering |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-200876 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
| Fachbereich(e)/-gebiet(e): | 05 Fachbereich Physik 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) 05 Fachbereich Physik > Institut für Physik Kondensierter Materie (IPKM) > Physik biologischer weicher Materie |
| Hinterlegungsdatum: | 14 Nov 2023 14:19 |
| Letzte Änderung: | 15 Nov 2023 09:48 |
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| Suche nach Titel in: | TUfind oder in Google |
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