Knüppel, Finn ; Sun, Ang ; Wurm, Frank-Hendrik ; Hussong, Jeanette ; Torner, Benjamin (2023)
Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers.
In: Micromachines, 2023, 14 (8)
doi: 10.26083/tuprints-00024409
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed studies of local particle distributions of a particulate blood analog fluid are combined with wall shear stress and pressure loss measurements in two complementary set-ups with identical flow geometry, bulk Reynolds numbers and particle Reynolds numbers. For all investigated particle volume fractions of up to 5%, reductions in the stress and pressure loss were measured in comparison to a flow of an equivalent homogeneous fluid (without particles). We could explain this due to the formation of a CFL ranging from 10 to 20 μm. Variations in the channel Reynolds number between Re = 50 and 150 did not lead to measurable changes in CFL heights or stress reductions for all investigated particle volume fractions. These measurements were used to describe the complete chain of how CFL formation leads to a stress reduction, which reduces the apparent viscosity of the suspension and results in the Fåhræus–Lindqvist effect. This chain of causes was investigated for the first time for flows with high Reynolds numbers (Re∼100), representing a flow regime which can be found in the narrow gaps of a VAD.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Knüppel, Finn ; Sun, Ang ; Wurm, Frank-Hendrik ; Hussong, Jeanette ; Torner, Benjamin |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers |
| Sprache: | Englisch |
| Publikationsjahr: | 2023 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2023 |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Micromachines |
| Jahrgang/Volume einer Zeitschrift: | 14 |
| (Heft-)Nummer: | 8 |
| Kollation: | 22 Seiten |
| DOI: | 10.26083/tuprints-00024409 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/24409 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | In the present paper, we investigate how the reductions in shear stresses and pressure losses in microfluidic gaps are directly linked to the local characteristics of cell-free layers (CFLs) at channel Reynolds numbers relevant to ventricular assist device (VAD) applications. For this, detailed studies of local particle distributions of a particulate blood analog fluid are combined with wall shear stress and pressure loss measurements in two complementary set-ups with identical flow geometry, bulk Reynolds numbers and particle Reynolds numbers. For all investigated particle volume fractions of up to 5%, reductions in the stress and pressure loss were measured in comparison to a flow of an equivalent homogeneous fluid (without particles). We could explain this due to the formation of a CFL ranging from 10 to 20 μm. Variations in the channel Reynolds number between Re = 50 and 150 did not lead to measurable changes in CFL heights or stress reductions for all investigated particle volume fractions. These measurements were used to describe the complete chain of how CFL formation leads to a stress reduction, which reduces the apparent viscosity of the suspension and results in the Fåhræus–Lindqvist effect. This chain of causes was investigated for the first time for flows with high Reynolds numbers (Re∼100), representing a flow regime which can be found in the narrow gaps of a VAD. |
| Freie Schlagworte: | cell-free layer, particulate blood analog fluid, particle-laden flows, wall shear stress, astigmatism particle tracking velocimetry, apparent viscosity, Fåhræus–Lindqvist effect, microchannels, ventricular assist devices, gap flow |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-244097 |
| Zusätzliche Informationen: | This article belongs to the Special Issue Microfluidics in Biomedical Applications |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften und Maschinenbau |
| Fachbereich(e)/-gebiet(e): | 16 Fachbereich Maschinenbau 16 Fachbereich Maschinenbau > Fachgebiet Strömungslehre und Aerodynamik (SLA) |
| Hinterlegungsdatum: | 11 Aug 2023 12:12 |
| Letzte Änderung: | 15 Aug 2023 07:00 |
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| Suche nach Titel in: | TUfind oder in Google |
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- Effect of Particle Migration on the Stress Field in Microfluidic Flows of Blood Analog Fluids at High Reynolds Numbers. (deposited 11 Aug 2023 12:12) [Gegenwärtig angezeigt]
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