Scheithauer, Lina ; Karagöz, Mustafa Safa ; Mayer, Benjamin E. ; Steinert, Michael (2023)
Protein sociology of ProA, Mip and other secreted virulence factors at the Legionella pneumophila surface.
In: Frontiers in Cellular and Infection Microbiology, 2023, 13
doi: 10.26083/tuprints-00023383
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
The pathogenicity of L. pneumophila, the causative agent of Legionnaires’ disease, depends on an arsenal of interacting proteins. Here we describe how surface-associated and secreted virulence factors of this pathogen interact with each other or target extra- and intracellular host proteins resulting in host cell manipulation and tissue colonization. Since progress of computational methods like AlphaFold, molecular dynamics simulation, and docking allows to predict, analyze and evaluate experimental proteomic and interactomic data, we describe how the combination of these approaches generated new insights into the multifaceted “protein sociology” of the zinc metalloprotease ProA and the peptidyl-prolyl cis/trans isomerase Mip (macrophage infectivity potentiator). Both virulence factors of L. pneumophila interact with numerous proteins including bacterial flagellin (FlaA) and host collagen, and play important roles in virulence regulation, host tissue degradation and immune evasion. The recent progress in protein-ligand analyses of virulence factors suggests that machine learning will also have a beneficial impact in early stages of drug discovery.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Scheithauer, Lina ; Karagöz, Mustafa Safa ; Mayer, Benjamin E. ; Steinert, Michael |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Protein sociology of ProA, Mip and other secreted virulence factors at the Legionella pneumophila surface |
| Sprache: | Englisch |
| Publikationsjahr: | 2023 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2023 |
| Verlag: | Frontiers Media S.A. |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in Cellular and Infection Microbiology |
| Jahrgang/Volume einer Zeitschrift: | 13 |
| Kollation: | 21 Seiten |
| DOI: | 10.26083/tuprints-00023383 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/23383 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | The pathogenicity of L. pneumophila, the causative agent of Legionnaires’ disease, depends on an arsenal of interacting proteins. Here we describe how surface-associated and secreted virulence factors of this pathogen interact with each other or target extra- and intracellular host proteins resulting in host cell manipulation and tissue colonization. Since progress of computational methods like AlphaFold, molecular dynamics simulation, and docking allows to predict, analyze and evaluate experimental proteomic and interactomic data, we describe how the combination of these approaches generated new insights into the multifaceted “protein sociology” of the zinc metalloprotease ProA and the peptidyl-prolyl cis/trans isomerase Mip (macrophage infectivity potentiator). Both virulence factors of L. pneumophila interact with numerous proteins including bacterial flagellin (FlaA) and host collagen, and play important roles in virulence regulation, host tissue degradation and immune evasion. The recent progress in protein-ligand analyses of virulence factors suggests that machine learning will also have a beneficial impact in early stages of drug discovery. |
| Freie Schlagworte: | Legionella pneumophila, surface-associated proteins, secreted effectors, zinc metalloprotease ProA, macrophage infectivity potentiator, interactomics, computational biology |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-233837 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Computational Biology and Simulation |
| Hinterlegungsdatum: | 11 Apr 2023 11:55 |
| Letzte Änderung: | 12 Apr 2023 05:05 |
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| Suche nach Titel in: | TUfind oder in Google |
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- Protein sociology of ProA, Mip and other secreted virulence factors at the Legionella pneumophila surface. (deposited 11 Apr 2023 11:55) [Gegenwärtig angezeigt]
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