Frosch, T. ; Küstner, B. ; Schlücker, S. ; Szeghalmi, A. ; Schmitt, M. ; Kiefer, W. ; Popp, J. (2004)
In vitro polarization-resolved resonance Raman studies of the interaction of hematin with the antimalarial drug chloroquine.
In: Journal of Raman Spectroscopy, 35 (10)
doi: 10.1002/jrs.1252
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Despite the public health impact of human malaria, the mechanism of hemozoin inhibition by antimalarial drugs such as chloroquine (CQ) is not yet fully understood. Polarization-resolved resonance Raman spectra of hematin and its complex with CQ were recorded under Q-band resonance conditions in order to monitor the binding of the 4-aminoquinoline drug to the heme macrocycle. Upon drug addition, only wavenumber shifts smaller than 2 cm−1 are detected, indicating a non-covalent interaction in the electronic ground state of the drug–target complex. The decreased resonance Raman intensity of the anomalously polarized mode ν19(a2g) in the perpendicular polarized spectrum of the complex suggests changes of the excited-state geometry along the corresponding normal coordinate.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2004 |
| Autor(en): | Frosch, T. ; Küstner, B. ; Schlücker, S. ; Szeghalmi, A. ; Schmitt, M. ; Kiefer, W. ; Popp, J. |
| Art des Eintrags: | Bibliographie |
| Titel: | In vitro polarization-resolved resonance Raman studies of the interaction of hematin with the antimalarial drug chloroquine |
| Sprache: | Englisch |
| Publikationsjahr: | Oktober 2004 |
| Verlag: | Wiley & Sons Ltd. |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of Raman Spectroscopy |
| Jahrgang/Volume einer Zeitschrift: | 35 |
| (Heft-)Nummer: | 10 |
| DOI: | 10.1002/jrs.1252 |
| Kurzbeschreibung (Abstract): | Despite the public health impact of human malaria, the mechanism of hemozoin inhibition by antimalarial drugs such as chloroquine (CQ) is not yet fully understood. Polarization-resolved resonance Raman spectra of hematin and its complex with CQ were recorded under Q-band resonance conditions in order to monitor the binding of the 4-aminoquinoline drug to the heme macrocycle. Upon drug addition, only wavenumber shifts smaller than 2 cm−1 are detected, indicating a non-covalent interaction in the electronic ground state of the drug–target complex. The decreased resonance Raman intensity of the anomalously polarized mode ν19(a2g) in the perpendicular polarized spectrum of the complex suggests changes of the excited-state geometry along the corresponding normal coordinate. |
| Freie Schlagworte: | Drug Target Interaction, Drug Sensing, Antimalarial Drug, Chloroquine, Hematin, Resonance Raman Spectroscopy, Malaria, Biomedical Spectroscopy, Pharmaceutical Spectroscopy |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Biophotonik-Medizintechnik |
| Hinterlegungsdatum: | 19 Jan 2024 10:42 |
| Letzte Änderung: | 19 Jan 2024 18:07 |
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