Cînta-Pînzaru, S. ; Peica, N. ; Küstner, B. ; Schlücker, S. ; Schmitt, M. ; Frosch, T. ; Faber, J. H. ; Bringmann, G. ; Popp, J. (2006)
FT-Raman and NIR-SERS characterization of the antimalarial drugs chloroquine and mefloquine and their interaction with hematin.
In: Journal of Raman Spectroscopy, 37 (1-3)
doi: 10.1002/jrs.1471
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Raman and surface-enhanced Raman scattering (SERS) spectroscopies were employed to probe the interaction of the antimalarial drugs chloroquine (CQ) and mefloquine (MQ) with hematin. NIR-SERS spectra of both quinoline derivatives were obtained from a colloidal gold surface. Strong chemical interactions of each drug with the Au particles are observed and the similarities of the two NIR-SERS spectra allowed to predict a similar orientation geometry for both of the drugs on the colloidal surface, namely through the quinoline skeletal part of each molecular structure.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2006 |
| Autor(en): | Cînta-Pînzaru, S. ; Peica, N. ; Küstner, B. ; Schlücker, S. ; Schmitt, M. ; Frosch, T. ; Faber, J. H. ; Bringmann, G. ; Popp, J. |
| Art des Eintrags: | Bibliographie |
| Titel: | FT-Raman and NIR-SERS characterization of the antimalarial drugs chloroquine and mefloquine and their interaction with hematin |
| Sprache: | Englisch |
| Publikationsjahr: | 12 Januar 2006 |
| Verlag: | Wiley & Sons Ltd. |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of Raman Spectroscopy |
| Jahrgang/Volume einer Zeitschrift: | 37 |
| (Heft-)Nummer: | 1-3 |
| DOI: | 10.1002/jrs.1471 |
| Kurzbeschreibung (Abstract): | Raman and surface-enhanced Raman scattering (SERS) spectroscopies were employed to probe the interaction of the antimalarial drugs chloroquine (CQ) and mefloquine (MQ) with hematin. NIR-SERS spectra of both quinoline derivatives were obtained from a colloidal gold surface. Strong chemical interactions of each drug with the Au particles are observed and the similarities of the two NIR-SERS spectra allowed to predict a similar orientation geometry for both of the drugs on the colloidal surface, namely through the quinoline skeletal part of each molecular structure. |
| Freie Schlagworte: | Biomedical Spectroscopy, Pharmaceutical Spectroscopy, Drug Target Interactions, Drug Sensing, Biomedical Sensing, Antimalarial Drug, Chloroquine, Mefloquine, Raman, NIR-SERS, Hematin, Malaria |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Biophotonik-Medizintechnik |
| Hinterlegungsdatum: | 19 Jan 2024 10:40 |
| Letzte Änderung: | 14 Mai 2024 08:21 |
| PPN: | 518250520 |
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