Frosch, Torsten ; Schmitt, Michael ; Schenzel, Karla ; Faber, Johan H. ; Bringmann, Gerhard ; Kiefer, Wolfgang ; Popp, Jürgen (2006)
In vivo localization and identification of the antiplasmodial alkaloid dioncophylline A in the tropical lianaTriphyophyllum peltatum by a combination of fluorescence, near infrared Fourier transform Raman microscopy, and density functional theory calculations.
In: Biopolymers, 82 (4)
doi: 10.1002/bip.20459
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Near infrared Fourier transform (NIR FT) micro Raman spectroscopy in combination with density functional theory (DFT) calculations has been applied for an in vivo localization of the antiplasmodial naphthylisoquinoline alkaloid dioncophylline A (1) in the tropical liana Triphyophyllum peltatum. Fluorescence microscopy images suggest finding this active agent in 10 μm big inclusions located in the cortex of the stem or the beginning of the leaves. By means of spatially resolved FT Raman micro spectroscopy, we could detect dioncophylline A (1) in these inclusions. FT Raman spectroscopy is an extremely selective tool capable of differentiating between various structurally similar naphthylisoquinoline alkaloids. With the help of DFT calculations, we succeeded in assigning the differences found in the FT Raman spectra of the various naphthylisoquinolines to νCC vibrations of the naphthyl ring. The presented results are of relevance for the investigation and extraction of new antimalarial active agents. © 2006 Wiley Periodicals, Inc. Biopolymers 82: 295–300, 2006
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2006 |
| Autor(en): | Frosch, Torsten ; Schmitt, Michael ; Schenzel, Karla ; Faber, Johan H. ; Bringmann, Gerhard ; Kiefer, Wolfgang ; Popp, Jürgen |
| Art des Eintrags: | Bibliographie |
| Titel: | In vivo localization and identification of the antiplasmodial alkaloid dioncophylline A in the tropical lianaTriphyophyllum peltatum by a combination of fluorescence, near infrared Fourier transform Raman microscopy, and density functional theory calculations |
| Sprache: | Englisch |
| Publikationsjahr: | 1 Februar 2006 |
| Verlag: | Wiley Periodicals |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Biopolymers |
| Jahrgang/Volume einer Zeitschrift: | 82 |
| (Heft-)Nummer: | 4 |
| DOI: | 10.1002/bip.20459 |
| Kurzbeschreibung (Abstract): | Near infrared Fourier transform (NIR FT) micro Raman spectroscopy in combination with density functional theory (DFT) calculations has been applied for an in vivo localization of the antiplasmodial naphthylisoquinoline alkaloid dioncophylline A (1) in the tropical liana Triphyophyllum peltatum. Fluorescence microscopy images suggest finding this active agent in 10 μm big inclusions located in the cortex of the stem or the beginning of the leaves. By means of spatially resolved FT Raman micro spectroscopy, we could detect dioncophylline A (1) in these inclusions. FT Raman spectroscopy is an extremely selective tool capable of differentiating between various structurally similar naphthylisoquinoline alkaloids. With the help of DFT calculations, we succeeded in assigning the differences found in the FT Raman spectra of the various naphthylisoquinolines to νCC vibrations of the naphthyl ring. The presented results are of relevance for the investigation and extraction of new antimalarial active agents. © 2006 Wiley Periodicals, Inc. Biopolymers 82: 295–300, 2006 |
| Freie Schlagworte: | in situ, Biomedical Sensing, Drug Sensing, Antimalarial, Alkaloid Dioncophylline, in Plant, Fluorescence, NIR-FT, Raman Microscopy, density functional theory DFT calculations, Malaria, Biomedical Spectroscopy, Pharmaceutical Spectroscopy |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Biophotonik-Medizintechnik |
| Hinterlegungsdatum: | 19 Jan 2024 10:41 |
| Letzte Änderung: | 19 Jan 2024 18:06 |
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