Frosch, Torsten ; Koncarevic, Sasa ; Becker, Katja ; Popp, Jürgen (2009)
Morphology-sensitive Raman modes of the malaria pigment hemozoin.
In: Analyst, 134 (6)
doi: 10.1039/b821705j
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Resonance Raman spectroscopy was applied for investigating the malaria pigment hemozoin, which is an important target structure of antimalarialdrugs. Morphology-sensitive low wavenumber modes of hemozoin were selectively enhanced with help of excitation wavelengths at λ = 633 nm and λ = 647 nm. The assignment of the most prominent bands in the Raman spectra at 343 cm−1 and 368 cm−1 was assisted by DFT calculations of the hemozoin dimer. The mode at 343 cm−1 in the Raman spectrum of hemozoin is strongly enhanced with λexc. = 647 nm and is represented by a combined, symmetric doming mode of the two hematin units in the hemozoin dimer. The enhancement of this vibration is stronger in the resonance Raman spectrum of hemozoin compared with less crystalline β-hematin. The selective resonance enhancement of the morphology-sensitive Raman modes of hemozoin is caused by absorption bands in the UV-VIS-NIR spectrum. This absorption spectrum of the crystalline malaria pigment hemozoin shows a strong band at 655 nm. Another broad absorption band at 870 nm is the reason for the strong relative resonance enhancement of the mode at 1372 cm−1 in the Raman spectrum of crystalline hemozoin with λexc. = 830 nm. In conclusion, resonance Raman micro-spectroscopy with λexc. = 647 nm was shown to have great potential as an analytical tool to probe the morphology of hematin samples.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2009 |
| Autor(en): | Frosch, Torsten ; Koncarevic, Sasa ; Becker, Katja ; Popp, Jürgen |
| Art des Eintrags: | Bibliographie |
| Titel: | Morphology-sensitive Raman modes of the malaria pigment hemozoin |
| Sprache: | Englisch |
| Publikationsjahr: | 9 April 2009 |
| Verlag: | Royal Society of Chemistry |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Analyst |
| Jahrgang/Volume einer Zeitschrift: | 134 |
| (Heft-)Nummer: | 6 |
| DOI: | 10.1039/b821705j |
| Kurzbeschreibung (Abstract): | Resonance Raman spectroscopy was applied for investigating the malaria pigment hemozoin, which is an important target structure of antimalarialdrugs. Morphology-sensitive low wavenumber modes of hemozoin were selectively enhanced with help of excitation wavelengths at λ = 633 nm and λ = 647 nm. The assignment of the most prominent bands in the Raman spectra at 343 cm−1 and 368 cm−1 was assisted by DFT calculations of the hemozoin dimer. The mode at 343 cm−1 in the Raman spectrum of hemozoin is strongly enhanced with λexc. = 647 nm and is represented by a combined, symmetric doming mode of the two hematin units in the hemozoin dimer. The enhancement of this vibration is stronger in the resonance Raman spectrum of hemozoin compared with less crystalline β-hematin. The selective resonance enhancement of the morphology-sensitive Raman modes of hemozoin is caused by absorption bands in the UV-VIS-NIR spectrum. This absorption spectrum of the crystalline malaria pigment hemozoin shows a strong band at 655 nm. Another broad absorption band at 870 nm is the reason for the strong relative resonance enhancement of the mode at 1372 cm−1 in the Raman spectrum of crystalline hemozoin with λexc. = 830 nm. In conclusion, resonance Raman micro-spectroscopy with λexc. = 647 nm was shown to have great potential as an analytical tool to probe the morphology of hematin samples. |
| Freie Schlagworte: | Malaria, Malaria Pigment Hemozoin, Analysis, Pharma, Biomedical Spectroscopy, Pharmaceutical Spectroscopy, Resonance Raman Spectroscopy, Raman Microscopy, density functional theory DFT calculations |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Biophotonik-Medizintechnik |
| Hinterlegungsdatum: | 19 Jan 2024 10:32 |
| Letzte Änderung: | 19 Jan 2024 17:47 |
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