Hanf, Stefan ; Keiner, Robert ; Yan, Di ; Popp, Jürgen ; Frosch, Torsten (2014)
Fiber-Enhanced Raman Multigas Spectroscopy: A Versatile Tool for Environmental Gas Sensing and Breath Analysis.
In: Analytical Chemistry, 86 (11)
doi: 10.1021/ac404162w
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Versatile multigas analysis bears high potential for environmental sensing of climate relevant gases and noninvasive early stage diagnosis of disease states in human breath. In this contribution, a fiber-enhanced Raman spectroscopic (FERS) analysis of a suite of climate relevant atmospheric gases is presented, which allowed for reliable quantification of CH4, CO2, and N2O alongside N2 and O2 with just one single measurement. A highly improved analytical sensitivity was achieved, down to a sub-parts per million limit of detection with a high dynamic range of 6 orders of magnitude and within a second measurement time. The high potential of FERS for the detection of disease markers was demonstrated with the analysis of 27 nL of exhaled human breath. The natural isotopes 13CO2 and 14N15N were quantified at low levels, simultaneously with the major breath components N2, O2, and 12CO2. The natural abundances of 13CO2 and 14N15N were experimentally quantified in very good agreement to theoretical values. A fiber adapter assembly and gas filling setup was designed for rapid and automated analysis of multigas compositions and their fluctuations within seconds and without the need for optical readjustment of the sensor arrangement. On the basis of the abilities of such miniaturized FERS system, we expect high potential for the diagnosis of clinically administered 13C-labeled CO2 in human breath and also foresee high impact for disease detection via biologically vital nitrogen compounds.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2014 |
| Autor(en): | Hanf, Stefan ; Keiner, Robert ; Yan, Di ; Popp, Jürgen ; Frosch, Torsten |
| Art des Eintrags: | Bibliographie |
| Titel: | Fiber-Enhanced Raman Multigas Spectroscopy: A Versatile Tool for Environmental Gas Sensing and Breath Analysis |
| Sprache: | Englisch |
| Publikationsjahr: | 3 Juni 2014 |
| Verlag: | ACS Publications |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Analytical Chemistry |
| Jahrgang/Volume einer Zeitschrift: | 86 |
| (Heft-)Nummer: | 11 |
| DOI: | 10.1021/ac404162w |
| Kurzbeschreibung (Abstract): | Versatile multigas analysis bears high potential for environmental sensing of climate relevant gases and noninvasive early stage diagnosis of disease states in human breath. In this contribution, a fiber-enhanced Raman spectroscopic (FERS) analysis of a suite of climate relevant atmospheric gases is presented, which allowed for reliable quantification of CH4, CO2, and N2O alongside N2 and O2 with just one single measurement. A highly improved analytical sensitivity was achieved, down to a sub-parts per million limit of detection with a high dynamic range of 6 orders of magnitude and within a second measurement time. The high potential of FERS for the detection of disease markers was demonstrated with the analysis of 27 nL of exhaled human breath. The natural isotopes 13CO2 and 14N15N were quantified at low levels, simultaneously with the major breath components N2, O2, and 12CO2. The natural abundances of 13CO2 and 14N15N were experimentally quantified in very good agreement to theoretical values. A fiber adapter assembly and gas filling setup was designed for rapid and automated analysis of multigas compositions and their fluctuations within seconds and without the need for optical readjustment of the sensor arrangement. On the basis of the abilities of such miniaturized FERS system, we expect high potential for the diagnosis of clinically administered 13C-labeled CO2 in human breath and also foresee high impact for disease detection via biologically vital nitrogen compounds. |
| Freie Schlagworte: | Fiber Enhanced Raman Spectroscopy FERS, Biomedical Spectroscopy, Breath Analysis, Gas Analysis, Ecological Gas Sensing, Environmental Gas Sensing, hollow core photonic crystal fiber |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Biophotonik-Medizintechnik |
| Hinterlegungsdatum: | 19 Jan 2024 10:24 |
| Letzte Änderung: | 19 Jan 2024 17:22 |
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