Yan, Di ; Popp, Jürgen ; Pletz, Mathias W. ; Frosch, Torsten (2017)
Highly Sensitive Broadband Raman Sensing of Antibiotics in Step-Index Hollow-Core Photonic Crystal Fibers.
In: ACS Photonics, 4 (1)
doi: 10.1021/acsphotonics.6b00688
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Broadband fiber enhanced Raman spectroscopy (FERS) in aqueous media is introduced in elaborated hollow-core photonic crystal fibers. The high requirements on the filigree fiber structure were thoroughly analyzed. A preparation technique was developed for the precise selective filling of such high-performance sensor fibers. Broadband step-index light guidance in aqueous solutions was achieved for the first time in photonic crystal fibers across the whole visible and NIR spectral range. Thus, strong Raman signal enhancements could be demonstrated with various excitation wavelengths and for the high-wavenumber region. The novel fiber enhancement technique was exploited for low-concentration measurements of the frequently used broad-spectrum antibiotic moxifloxacin down to 1.7 μM in only a 4 nL sample volume. These unique abilities for chemical-selective, highly sensitive antibiotic monitoring will pave the way for rapid, minimally invasive analysis of antibiotic concentrations in serum and other body fluids from infected sites. This will allow a precise therapeutic drug monitoring and consecutive rapid dose adjustment in critically ill patients who require individual dosing due to large inter- and intraindividual changes in pharmacokinetic properties.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2017 |
| Autor(en): | Yan, Di ; Popp, Jürgen ; Pletz, Mathias W. ; Frosch, Torsten |
| Art des Eintrags: | Bibliographie |
| Titel: | Highly Sensitive Broadband Raman Sensing of Antibiotics in Step-Index Hollow-Core Photonic Crystal Fibers |
| Sprache: | Englisch |
| Publikationsjahr: | 4 Januar 2017 |
| Verlag: | ACS Publications |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | ACS Photonics |
| Jahrgang/Volume einer Zeitschrift: | 4 |
| (Heft-)Nummer: | 1 |
| DOI: | 10.1021/acsphotonics.6b00688 |
| Kurzbeschreibung (Abstract): | Broadband fiber enhanced Raman spectroscopy (FERS) in aqueous media is introduced in elaborated hollow-core photonic crystal fibers. The high requirements on the filigree fiber structure were thoroughly analyzed. A preparation technique was developed for the precise selective filling of such high-performance sensor fibers. Broadband step-index light guidance in aqueous solutions was achieved for the first time in photonic crystal fibers across the whole visible and NIR spectral range. Thus, strong Raman signal enhancements could be demonstrated with various excitation wavelengths and for the high-wavenumber region. The novel fiber enhancement technique was exploited for low-concentration measurements of the frequently used broad-spectrum antibiotic moxifloxacin down to 1.7 μM in only a 4 nL sample volume. These unique abilities for chemical-selective, highly sensitive antibiotic monitoring will pave the way for rapid, minimally invasive analysis of antibiotic concentrations in serum and other body fluids from infected sites. This will allow a precise therapeutic drug monitoring and consecutive rapid dose adjustment in critically ill patients who require individual dosing due to large inter- and intraindividual changes in pharmacokinetic properties. |
| Freie Schlagworte: | Fluorochinolone, Antibiotic, Moxifloxacin, Pharma, Fiber Enhanced Raman Spectroscopy FERS, Biomedical Sensing, Drug Sensing, Therapeutical Drug Monitoring, TDM, Biomedical Spectroscopy, Pharmaceutical Spectroscopy, hollow core photonic crystal fiber HC PCF |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Biophotonik-Medizintechnik |
| Hinterlegungsdatum: | 18 Jan 2024 11:41 |
| Letzte Änderung: | 11 Mär 2024 16:02 |
| PPN: | 516224255 |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
 |
Frage zum Eintrag |
Optionen (nur für Redakteure)
 |
Redaktionelle Details anzeigen |
Drucken
Impressum