Yan, Di ; Frosch, Timea ; Kobelke, Jens ; Bierlich, Jörg ; Popp, Jürgen ; Pletz, Mathias W. ; Frosch, Torsten (2018)
Fiber-Enhanced Raman Sensing of Cefuroxime in Human Urine.
In: Analytical Chemistry, 90 (22)
doi: 10.1021/acs.analchem.8b01355
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Fiber-enhanced Raman spectroscopy was developed for the chemically selective and sensitive quantification of the important antibiotic cefuroxime in human urine. A novel optical sensor fiber was drawn and precisely prepared. In this fiber structure, light is strongly confined in the selectively filled liquid core, and the Raman scattered signal is collected with unprecedented efficiency over an extended interaction length. The filling, emptying, and robustness are highly improved due to the large core size (>30 μm). Broadband step-index guidance allows the free choice of the most suitable excitation wavelength in complex body fluids. The limit of detection of cefuroxime in human urine was improved by 2 orders of magnitude (to μM level). The quantification of cefuroxime was achieved in urine after oral administration. This method has great potential for the point-of-care monitoring of antibiotics concentrations and is an important step forward to enable clinicians to rapidly adjust doses.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2018 |
| Autor(en): | Yan, Di ; Frosch, Timea ; Kobelke, Jens ; Bierlich, Jörg ; Popp, Jürgen ; Pletz, Mathias W. ; Frosch, Torsten |
| Art des Eintrags: | Bibliographie |
| Titel: | Fiber-Enhanced Raman Sensing of Cefuroxime in Human Urine |
| Sprache: | Englisch |
| Publikationsjahr: | 2 November 2018 |
| Verlag: | ACS Publications |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Analytical Chemistry |
| Jahrgang/Volume einer Zeitschrift: | 90 |
| (Heft-)Nummer: | 22 |
| DOI: | 10.1021/acs.analchem.8b01355 |
| Kurzbeschreibung (Abstract): | Fiber-enhanced Raman spectroscopy was developed for the chemically selective and sensitive quantification of the important antibiotic cefuroxime in human urine. A novel optical sensor fiber was drawn and precisely prepared. In this fiber structure, light is strongly confined in the selectively filled liquid core, and the Raman scattered signal is collected with unprecedented efficiency over an extended interaction length. The filling, emptying, and robustness are highly improved due to the large core size (>30 μm). Broadband step-index guidance allows the free choice of the most suitable excitation wavelength in complex body fluids. The limit of detection of cefuroxime in human urine was improved by 2 orders of magnitude (to μM level). The quantification of cefuroxime was achieved in urine after oral administration. This method has great potential for the point-of-care monitoring of antibiotics concentrations and is an important step forward to enable clinicians to rapidly adjust doses. |
| Freie Schlagworte: | Fiber Enhanced Raman Spectroscopy FERS, Beta-Lactam Cephalosporin Antibiotics, Cefuroxime, Urine, Pharma, Drug Sensing, Biomedical Sensing, Therapeutical Drug Monitoring TDM, Bodyfluid, Biomedical Spectroscopy, Pharmaceutical Spectroscopy, hollow core antiresonant fiber |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Biophotonik-Medizintechnik |
| Hinterlegungsdatum: | 18 Jan 2024 11:13 |
| Letzte Änderung: | 07 Mär 2024 10:42 |
| PPN: | 516068032 |
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