Azkune, Mikel ; Frosch, Timea ; Arrospide, Eneko ; Aldabaldetreku, Gotzon ; Bikandi, Inaki ; Zubia, Joseba ; Popp, Jürgen ; Frosch, Torsten (2019)
Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing.
In: Journal of Lightwave Technology, 37 (13)
doi: 10.1109/JLT.2019.2908447
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
This work reports the development and application of two liquid-core microstructured polymer optical fibers (LC-mPOF) with different microstructure sizes. They are used in a fiber-enhanced Raman spectroscopy sensing platform, with the aim of detecting glucose in aqueous solutions in the clinically relevant range for sodium-glucose cotransporter 2 inhibitor therapy. The sensing platform is tested for low-concentration glucose solutions using each LC-mPOF. Results confirm that a significant enhancement of the Raman signal is achieved in comparison to conventional Raman spectroscopy. Additional measurements are carried out to obtain the valid measurement range, the resolution, and the limit of detection, showing that the LC-mPOF with 66-μm-diameter central hollow core has the highest potential for future clinical applications. Finally, preliminary tests successfully demonstrate glucose identification in urine.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2019 |
| Autor(en): | Azkune, Mikel ; Frosch, Timea ; Arrospide, Eneko ; Aldabaldetreku, Gotzon ; Bikandi, Inaki ; Zubia, Joseba ; Popp, Jürgen ; Frosch, Torsten |
| Art des Eintrags: | Bibliographie |
| Titel: | Liquid-Core Microstructured Polymer Optical Fiber as Fiber-Enhanced Raman Spectroscopy Probe for Glucose Sensing |
| Sprache: | Englisch |
| Publikationsjahr: | 1 Juli 2019 |
| Verlag: | IEEE |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Journal of Lightwave Technology |
| Jahrgang/Volume einer Zeitschrift: | 37 |
| (Heft-)Nummer: | 13 |
| DOI: | 10.1109/JLT.2019.2908447 |
| Kurzbeschreibung (Abstract): | This work reports the development and application of two liquid-core microstructured polymer optical fibers (LC-mPOF) with different microstructure sizes. They are used in a fiber-enhanced Raman spectroscopy sensing platform, with the aim of detecting glucose in aqueous solutions in the clinically relevant range for sodium-glucose cotransporter 2 inhibitor therapy. The sensing platform is tested for low-concentration glucose solutions using each LC-mPOF. Results confirm that a significant enhancement of the Raman signal is achieved in comparison to conventional Raman spectroscopy. Additional measurements are carried out to obtain the valid measurement range, the resolution, and the limit of detection, showing that the LC-mPOF with 66-μm-diameter central hollow core has the highest potential for future clinical applications. Finally, preliminary tests successfully demonstrate glucose identification in urine. |
| Freie Schlagworte: | Fiber Enhanced Raman Spectroscopy FERS, Glucose Sensing, Pharma, Therapeutical Drug Monitoring TDM, Sodium-Glucose-Co-transporter 2 (SGLT2) inhibitor, Urine, Bodyfluid, Diabetes, Drug Sensing, Biomedical Sensing, Biomedical Spectroscopy, Pharmaceutical Spectroscopy, hollow core polymer fiber |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Biophotonik-Medizintechnik |
| Hinterlegungsdatum: | 18 Jan 2024 11:12 |
| Letzte Änderung: | 20 Mär 2024 14:13 |
| PPN: | 515995665 |
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