Frosch, Torsten ; Knebl, Andreas ; Frosch, Timea (2019)
Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy.
In: Nanophotonics, 9 (1)
doi: 10.1515/nanoph-2019-0401
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
Innovations in Raman spectroscopic techniques provide a potential solution to current problems in pharmaceutical drug monitoring. This review aims to summarize the recent advances in the field. The developments of novel plasmonic nanoparticles continuously push the limits of Raman spectroscopic detection. In surface-enhanced Raman spectroscopy (SERS), these particles are used for the strong local enhancement of Raman signals from pharmaceutical drugs. SERS is increasingly applied for forensic trace detection and for therapeutic drug monitoring. In combination with spatially offset Raman spectroscopy, further application fields could be addressed, e.g. in situ pharmaceutical quality testing through the packaging. Raman optical activity, which enables the thorough analysis of specific chiral properties of drugs, can also be combined with SERS for signal enhancement. Besides SERS, micro- and nano-structured optical hollow fibers enable a versatile approach for Raman signal enhancement of pharmaceuticals. Within the fiber, the volume of interaction between drug molecules and laser light is increased compared with conventional methods. Advances in fiber-enhanced Raman spectroscopy point at the high potential for continuous online drug monitoring in clinical therapeutic diagnosis. Furthermore, fiber-array based non-invasive Raman spectroscopic chemical imaging of tablets might find application in the detection of substandard and counterfeit drugs. The discussed techniques are promising and might soon find widespread application for the detection and monitoring of drugs in various fields.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2019 |
| Autor(en): | Frosch, Torsten ; Knebl, Andreas ; Frosch, Timea |
| Art des Eintrags: | Bibliographie |
| Titel: | Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy |
| Sprache: | Englisch |
| Publikationsjahr: | 9 Dezember 2019 |
| Verlag: | De Gruyter |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Nanophotonics |
| Jahrgang/Volume einer Zeitschrift: | 9 |
| (Heft-)Nummer: | 1 |
| DOI: | 10.1515/nanoph-2019-0401 |
| Kurzbeschreibung (Abstract): | Innovations in Raman spectroscopic techniques provide a potential solution to current problems in pharmaceutical drug monitoring. This review aims to summarize the recent advances in the field. The developments of novel plasmonic nanoparticles continuously push the limits of Raman spectroscopic detection. In surface-enhanced Raman spectroscopy (SERS), these particles are used for the strong local enhancement of Raman signals from pharmaceutical drugs. SERS is increasingly applied for forensic trace detection and for therapeutic drug monitoring. In combination with spatially offset Raman spectroscopy, further application fields could be addressed, e.g. in situ pharmaceutical quality testing through the packaging. Raman optical activity, which enables the thorough analysis of specific chiral properties of drugs, can also be combined with SERS for signal enhancement. Besides SERS, micro- and nano-structured optical hollow fibers enable a versatile approach for Raman signal enhancement of pharmaceuticals. Within the fiber, the volume of interaction between drug molecules and laser light is increased compared with conventional methods. Advances in fiber-enhanced Raman spectroscopy point at the high potential for continuous online drug monitoring in clinical therapeutic diagnosis. Furthermore, fiber-array based non-invasive Raman spectroscopic chemical imaging of tablets might find application in the detection of substandard and counterfeit drugs. The discussed techniques are promising and might soon find widespread application for the detection and monitoring of drugs in various fields. |
| Freie Schlagworte: | Review Raman Spectroscopy for Pharmaceutical Drug Monitoring, Pharma, Biomedical Sensing, Drug Sensing, Therapeutical Drug Monitoring TDM, Fake, Counterfeit, FERS, SERS, SORS, ROA, Fiber Array based Chemical Imaging, Biomedical Spectroscopy, Pharmaceutical Spectroscopy |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Biophotonik-Medizintechnik |
| Hinterlegungsdatum: | 18 Jan 2024 10:36 |
| Letzte Änderung: | 01 Mär 2024 09:49 |
| PPN: | 515950718 |
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| Suche nach Titel in: | TUfind oder in Google |
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