Richter, Merle ; Loth, Yannik ; Weisenstein, Christian ; Wigger, Anna Katharina ; Schaar, Dominik ; Bosserhoff, Anja Katrin ; Haring Bolívar, Peter (2023)
Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics.
In: Frequenz, 2022, 76 (11-12)
doi: 10.26083/tuprints-00023208
Artikel, Zweitveröffentlichung, Verlagsversion
Kurzbeschreibung (Abstract)
Terahertz (THz) biosensing has emerged as an important research field, mainly driven by the resonant behavior of many biomolecules in this spectral range which holds potential for highly sensitive analyses. In this work, we present a detailed overview of our current research on THz biosensing, focusing on the development and analysis of THz biosensors based on frequency selective surfaces (FSS) for two different measurement scenarios: i) label-free, highly sensitive and selective analysis of dried biomolecules, and ii) sensitive and selective analysis in an aqueous environment. With our carefully designed THz biosensor for measurements in the dry state, we were able to indirectly measure tumor-marker MIA RNA in a concentration as low as 1.55 × 1E−12 mol/L, without the need for biochemical amplification. Our biosensor with substrate-integrated microfluidics for terahertz measurements in an aqueous environment is validated by simulations, showing that the resonance feature in the frequency response of our sensor is maintained even for measurements in water.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Richter, Merle ; Loth, Yannik ; Weisenstein, Christian ; Wigger, Anna Katharina ; Schaar, Dominik ; Bosserhoff, Anja Katrin ; Haring Bolívar, Peter |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Ultrasensitive marker-free biomolecular THz-detection for tumor-related analytics |
| Sprache: | Englisch |
| Publikationsjahr: | 2023 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2022 |
| Verlag: | De Gruyter |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frequenz |
| Jahrgang/Volume einer Zeitschrift: | 76 |
| (Heft-)Nummer: | 11-12 |
| DOI: | 10.26083/tuprints-00023208 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/23208 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung |
| Kurzbeschreibung (Abstract): | Terahertz (THz) biosensing has emerged as an important research field, mainly driven by the resonant behavior of many biomolecules in this spectral range which holds potential for highly sensitive analyses. In this work, we present a detailed overview of our current research on THz biosensing, focusing on the development and analysis of THz biosensors based on frequency selective surfaces (FSS) for two different measurement scenarios: i) label-free, highly sensitive and selective analysis of dried biomolecules, and ii) sensitive and selective analysis in an aqueous environment. With our carefully designed THz biosensor for measurements in the dry state, we were able to indirectly measure tumor-marker MIA RNA in a concentration as low as 1.55 × 1E−12 mol/L, without the need for biochemical amplification. Our biosensor with substrate-integrated microfluidics for terahertz measurements in an aqueous environment is validated by simulations, showing that the resonance feature in the frequency response of our sensor is maintained even for measurements in water. |
| Freie Schlagworte: | biomedical spectroscopy, biosensing, fano resonance, metamaterial, microfluidics, terahertz |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-232089 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 600 Technik 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften und Maschinenbau |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Mikrowellentechnik und Photonik (IMP) |
| Hinterlegungsdatum: | 01 Mär 2023 10:15 |
| Letzte Änderung: | 06 Mär 2023 11:03 |
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