Ghosh, Eashika ; Egunov, Aleksandr I. ; Karnaushenko, Daniil ; Medina-Sánchez, Mariana ; Schmidt, Oliver G. (2023)
Self-assembled sensor-in-a-tube as a versatile tool for label-free EIS viability investigation of cervical cancer cells.
In: Frequenz, 2022, 76 (11-12)
doi: 10.26083/tuprints-00023217
Artikel, Zweitveröffentlichung, Verlagsversion
Kurzbeschreibung (Abstract)
The advancement of micro and nanotechnology has led to the manufacturing of miniaturized sensors with improved functionalities for highly sensitive point of care devices. This work is particularly focused on analysing cancer cells and the effect of a model drug on their survival rate. To that end, we developed a highly sensitive rolled-up micro-electrochemical impedance spectroscopy sensor, encapsulated into a microfluidic channel. The sensor was built by strain engineering of shapeable materials and with diameters close to the cell size to improve their sensitivity. To demonstrate the platform performance, we first carried out measurements with different electrode geometries using cell medium at different concentrations. We also performed measurements using cancer cell suspensions, obtaining distinct signals from single cells, cell clusters and cellular debris. Finally, cancer cells were treated with an anticancer drug (Camptothecin), at different concentrations, over the same period, and further analysed using the developed platform.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2023 |
| Autor(en): | Ghosh, Eashika ; Egunov, Aleksandr I. ; Karnaushenko, Daniil ; Medina-Sánchez, Mariana ; Schmidt, Oliver G. |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Self-assembled sensor-in-a-tube as a versatile tool for label-free EIS viability investigation of cervical cancer cells |
| Sprache: | Englisch |
| Publikationsjahr: | 2023 |
| Ort: | Darmstadt |
| Publikationsdatum der Erstveröffentlichung: | 2022 |
| Verlag: | De Gruyter |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frequenz |
| Jahrgang/Volume einer Zeitschrift: | 76 |
| (Heft-)Nummer: | 11-12 |
| DOI: | 10.26083/tuprints-00023217 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/23217 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung |
| Kurzbeschreibung (Abstract): | The advancement of micro and nanotechnology has led to the manufacturing of miniaturized sensors with improved functionalities for highly sensitive point of care devices. This work is particularly focused on analysing cancer cells and the effect of a model drug on their survival rate. To that end, we developed a highly sensitive rolled-up micro-electrochemical impedance spectroscopy sensor, encapsulated into a microfluidic channel. The sensor was built by strain engineering of shapeable materials and with diameters close to the cell size to improve their sensitivity. To demonstrate the platform performance, we first carried out measurements with different electrode geometries using cell medium at different concentrations. We also performed measurements using cancer cell suspensions, obtaining distinct signals from single cells, cell clusters and cellular debris. Finally, cancer cells were treated with an anticancer drug (Camptothecin), at different concentrations, over the same period, and further analysed using the developed platform. |
| Freie Schlagworte: | electrical impedance spectroscopy, lab-in-atube, label-free impedimetric sensor, shapeable materials technologies, single-cell analysis |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-232172 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 530 Physik 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften und Maschinenbau |
| Fachbereich(e)/-gebiet(e): | 18 Fachbereich Elektrotechnik und Informationstechnik 18 Fachbereich Elektrotechnik und Informationstechnik > Institut für Mikrowellentechnik und Photonik (IMP) |
| Hinterlegungsdatum: | 01 Mär 2023 09:58 |
| Letzte Änderung: | 06 Mär 2023 11:06 |
| PPN: | |
| Zugehörige Links: | |
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| Suche nach Titel in: | TUfind oder in Google |
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