Schätzlein, Eva ; Kicker, Christoph ; Söhling, Nicolas ; Ritz, Ulrike ; Neijhoft, Jonas ; Henrich, Dirk ; Frank, Johannes ; Marzi, Ingo ; Blaeser, Andreas (2022)
3D-printed PLA-bioglass scaffolds with controllable calcium release and MSC adhesion for bone tissue engineering.
In: Polymers, 14 (12)
doi: 10.3390/polym14122389
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
Large bone defects are commonly treated by replacement with auto- and allografts, which have substantial drawbacks including limited supply, donor site morbidity, and possible tissue rejection. This study aimed to improve bone defect treatment using a custom-made filament for tissue engineering scaffolds. The filament consists of biodegradable polylactide acid (PLA) and a varying amount (up to 20) of osteoconductive S53P4 bioglass. By employing an innovative, additive manufacturing technique, scaffolds with optimized physico-mechanical and biological properties were produced. The scaffolds feature adjustable macro- and microporosity (200–2000 µm) with adaptable mechanical properties (83–135 MPa). Additionally, controllable calcium release kinetics (0–0.25 nMol/µL after 24 h), tunable mesenchymal stem cell (MSC) adhesion potential (after 24 h by a factor of 14), and proliferation (after 168 h by a factor of 18) were attained. Microgrooves resulting from the 3D-printing process on the surface act as a nucleus for cell aggregation, thus being a potential cell niche for spheroid formation or possible cell guidance. The scaffold design with its adjustable biomechanics and the bioglass with its antimicrobial properties are of particular importance for the preclinical translation of the results. This study comprehensibly demonstrates the potential of a 3D-printed bioglass composite scaffold for the treatment of critical-sized bone defects.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Schätzlein, Eva ; Kicker, Christoph ; Söhling, Nicolas ; Ritz, Ulrike ; Neijhoft, Jonas ; Henrich, Dirk ; Frank, Johannes ; Marzi, Ingo ; Blaeser, Andreas |
| Art des Eintrags: | Bibliographie |
| Titel: | 3D-printed PLA-bioglass scaffolds with controllable calcium release and MSC adhesion for bone tissue engineering |
| Sprache: | Englisch |
| Publikationsjahr: | 2022 |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Polymers |
| Jahrgang/Volume einer Zeitschrift: | 14 |
| (Heft-)Nummer: | 12 |
| DOI: | 10.3390/polym14122389 |
| URL / URN: | https://www.mdpi.com/2073-4360/14/12/2389 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | Large bone defects are commonly treated by replacement with auto- and allografts, which have substantial drawbacks including limited supply, donor site morbidity, and possible tissue rejection. This study aimed to improve bone defect treatment using a custom-made filament for tissue engineering scaffolds. The filament consists of biodegradable polylactide acid (PLA) and a varying amount (up to 20) of osteoconductive S53P4 bioglass. By employing an innovative, additive manufacturing technique, scaffolds with optimized physico-mechanical and biological properties were produced. The scaffolds feature adjustable macro- and microporosity (200–2000 µm) with adaptable mechanical properties (83–135 MPa). Additionally, controllable calcium release kinetics (0–0.25 nMol/µL after 24 h), tunable mesenchymal stem cell (MSC) adhesion potential (after 24 h by a factor of 14), and proliferation (after 168 h by a factor of 18) were attained. Microgrooves resulting from the 3D-printing process on the surface act as a nucleus for cell aggregation, thus being a potential cell niche for spheroid formation or possible cell guidance. The scaffold design with its adjustable biomechanics and the bioglass with its antimicrobial properties are of particular importance for the preclinical translation of the results. This study comprehensibly demonstrates the potential of a 3D-printed bioglass composite scaffold for the treatment of critical-sized bone defects. |
| Fachbereich(e)/-gebiet(e): | 16 Fachbereich Maschinenbau 16 Fachbereich Maschinenbau > Institut für Druckmaschinen und Druckverfahren (IDD) |
| Hinterlegungsdatum: | 23 Jun 2022 05:20 |
| Letzte Änderung: | 29 Aug 2024 09:46 |
| PPN: | 495878421 |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
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3D-Printed PLA-Bioglass Scaffolds with Controllable Calcium Release and MSC Adhesion for Bone Tissue Engineering. (deposited 11 Jul 2022 13:29)
- 3D-printed PLA-bioglass scaffolds with controllable calcium release and MSC adhesion for bone tissue engineering. (deposited 23 Jun 2022 05:20) [Gegenwärtig angezeigt]
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