Kilb, Michelle Fiona ; Moos, Yannik ; Eckes, Stefanie ; Braun, Joy ; Ritz, Ulrike ; Nickel, Daniela ; Schmitz, Katja (2022)
An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates.
In: Biomedicines, 2022, 9 (11)
doi: 10.26083/tuprints-00020067
Artikel, Zweitveröffentlichung, Verlagsversion
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Kurzbeschreibung (Abstract)
The controlled release of antibiotics prevents the spread of pathogens and thereby improves healing processes in regenerative medicine. However, high concentrations may interfere with healing processes. It is therefore advantageous to use biodegradable materials for a controlled release. In particular, multilayer materials enable differential release at different surfaces. For this purpose, collagen sheets of different properties can be bonded by photochemical crosslinking. Here, we present the development and application of an easily accessible, additively manufactured sample holder to study the controlled release of vancomycin from modularly assembled collagen laminates in two directions. As proof-of-concept, we show that laminates of collagen sheets covalently linked by rose bengal and green light crosslinking (RGX) can be tightly inserted into the device without leakage from the upper to lower cavity. We used this sample holder to detect the release of vancomycin from symmetrically and asymmetrically loaded two-layer and three-layer collagen laminates into the upper and lower cavity of the sample holder. We show that these collagen laminates are characterized by a collagen type-dependent vancomycin release, enabling the control of antibiotic release profiles as well as the direction of antibiotic release.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Kilb, Michelle Fiona ; Moos, Yannik ; Eckes, Stefanie ; Braun, Joy ; Ritz, Ulrike ; Nickel, Daniela ; Schmitz, Katja |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates |
| Sprache: | Englisch |
| Publikationsjahr: | 2022 |
| Publikationsdatum der Erstveröffentlichung: | 2022 |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Biomedicines |
| Jahrgang/Volume einer Zeitschrift: | 9 |
| (Heft-)Nummer: | 11 |
| Kollation: | 13 Seiten |
| DOI: | 10.26083/tuprints-00020067 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/20067 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | The controlled release of antibiotics prevents the spread of pathogens and thereby improves healing processes in regenerative medicine. However, high concentrations may interfere with healing processes. It is therefore advantageous to use biodegradable materials for a controlled release. In particular, multilayer materials enable differential release at different surfaces. For this purpose, collagen sheets of different properties can be bonded by photochemical crosslinking. Here, we present the development and application of an easily accessible, additively manufactured sample holder to study the controlled release of vancomycin from modularly assembled collagen laminates in two directions. As proof-of-concept, we show that laminates of collagen sheets covalently linked by rose bengal and green light crosslinking (RGX) can be tightly inserted into the device without leakage from the upper to lower cavity. We used this sample holder to detect the release of vancomycin from symmetrically and asymmetrically loaded two-layer and three-layer collagen laminates into the upper and lower cavity of the sample holder. We show that these collagen laminates are characterized by a collagen type-dependent vancomycin release, enabling the control of antibiotic release profiles as well as the direction of antibiotic release. |
| Freie Schlagworte: | collagen, controlled release, crosslinking, vancomycin, additively manufactured sample holder |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-200673 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 540 Chemie 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin, Gesundheit 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften und Maschinenbau |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Clemens-Schöpf-Institut > Fachgebiet Biochemie 07 Fachbereich Chemie > Clemens-Schöpf-Institut 07 Fachbereich Chemie > Clemens-Schöpf-Institut > Fachgebiet Organische Chemie |
| Hinterlegungsdatum: | 29 Apr 2022 08:47 |
| Letzte Änderung: | 03 Jul 2024 02:57 |
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| Suche nach Titel in: | TUfind oder in Google |
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- An Additively Manufactured Sample Holder to Measure the Controlled Release of Vancomycin from Collagen Laminates. (deposited 29 Apr 2022 08:47) [Gegenwärtig angezeigt]
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