Bogorodskiy, Andrey ; Okhrimenko, Ivan ; Burkatovskii, Dmitrii ; Jakobs, Philipp ; Maslov, Ivan ; Gordeliy, Valentin ; Dencher, Norbert A. ; Gensch, Thomas ; Voos, Wolfgang ; Altschmied, Joachim ; Haendeler, Judith ; Borshchevskiy, Valentin (2022)
Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases.
In: Cells, 2022, 10 (12)
doi: 10.26083/tuprints-00020276
Artikel, Zweitveröffentlichung, Verlagsversion
Kurzbeschreibung (Abstract)
Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and two aqueous compartments. An extensive network of dedicated proteins is engaged in importing and sorting these nuclear-encoded proteins into their designated mitochondrial compartments. Defects in this fundamental system are related to a variety of pathologies, particularly engaging the most energy-demanding tissues. In this review, we summarize the state-of-the-art knowledge about the mitochondrial protein import machinery and describe the known interrelation of its failure with age-related neurodegenerative and cardiovascular diseases.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Bogorodskiy, Andrey ; Okhrimenko, Ivan ; Burkatovskii, Dmitrii ; Jakobs, Philipp ; Maslov, Ivan ; Gordeliy, Valentin ; Dencher, Norbert A. ; Gensch, Thomas ; Voos, Wolfgang ; Altschmied, Joachim ; Haendeler, Judith ; Borshchevskiy, Valentin |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Role of Mitochondrial Protein Import in Age-Related Neurodegenerative and Cardiovascular Diseases |
| Sprache: | Englisch |
| Publikationsjahr: | 2022 |
| Publikationsdatum der Erstveröffentlichung: | 2022 |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Cells |
| Jahrgang/Volume einer Zeitschrift: | 10 |
| (Heft-)Nummer: | 12 |
| Kollation: | 22 Seiten |
| DOI: | 10.26083/tuprints-00020276 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/20276 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung DeepGreen |
| Kurzbeschreibung (Abstract): | Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and two aqueous compartments. An extensive network of dedicated proteins is engaged in importing and sorting these nuclear-encoded proteins into their designated mitochondrial compartments. Defects in this fundamental system are related to a variety of pathologies, particularly engaging the most energy-demanding tissues. In this review, we summarize the state-of-the-art knowledge about the mitochondrial protein import machinery and describe the known interrelation of its failure with age-related neurodegenerative and cardiovascular diseases. |
| Freie Schlagworte: | mitochondria, mitochondrial protein import, age-related diseases, Alzheimer’s disease, Parkinson’s disease, cardiovascular disease, TERT, cardiolipin |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-202761 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 540 Chemie 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Clemens-Schöpf-Institut > Fachgebiet Biochemie |
| Hinterlegungsdatum: | 29 Apr 2022 09:10 |
| Letzte Änderung: | 02 Mai 2022 05:50 |
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| Zugehörige Links: | |
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