Llorens-Agost, Marta ; Ensminger, Michael ; Le, Hang Phuong ; Heyer, Wolf-Dietrich ; Löbrich, Markus (2021)
Turning end-joining upside down in mitosis.
In: Molecular & cellular oncology, 8 (6)
doi: 10.1080/23723556.2021.2007029
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be repressed in interphase, but promotes break repair in mitosis. The nature and induction time of breaks might determine their fate during mitosis.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2021 |
| Autor(en): | Llorens-Agost, Marta ; Ensminger, Michael ; Le, Hang Phuong ; Heyer, Wolf-Dietrich ; Löbrich, Markus |
| Art des Eintrags: | Bibliographie |
| Titel: | Turning end-joining upside down in mitosis |
| Sprache: | Englisch |
| Publikationsjahr: | 2021 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Molecular & cellular oncology |
| Jahrgang/Volume einer Zeitschrift: | 8 |
| (Heft-)Nummer: | 6 |
| DOI: | 10.1080/23723556.2021.2007029 |
| Kurzbeschreibung (Abstract): | How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be repressed in interphase, but promotes break repair in mitosis. The nature and induction time of breaks might determine their fate during mitosis. |
| ID-Nummer: | pmid:35419469 |
| Zusätzliche Informationen: | Artikel-ID: 2007029 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Radiation Biology and DNA Repair |
| Hinterlegungsdatum: | 19 Apr 2022 05:50 |
| Letzte Änderung: | 19 Apr 2022 05:51 |
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