Abdighahroudi, Mohammad Sajjad ; Lutze, Holger V. ; Schmidt, Torsten C. (2022)
Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography.
In: Analytical and Bioanalytical Chemistry, 2020, 412 (20)
doi: 10.26083/tuprints-00013304
Artikel, Zweitveröffentlichung, Verlagsversion
 | Es ist eine neuere Version dieses Eintrags verfügbar. |
Kurzbeschreibung (Abstract)
N-containing heterocycles (NCHs) are largely used as precursors for pharmaceuticals and can enter the environment. Some NCHs have been shown to be toxic, persistent, and very mobile in the environment. Thus, they have received increasing attention in the past years. However, the analysis of these polar compounds in environmental samples is still a challenge for liquid chromatography. This paper investigates the use of mixed-mode liquid chromatography (MMLC), which has reversed-phase and ion exchange characteristics for measurements of NCHs in water. NCHs with low pKa (i.e., < 2.5) display mainly reversed-phase interactions (neutral species) with the stationary phase and those with higher pKa (i.e., > 5) interact by a mixture of reversed-phase/ion exchange/HILIC mechanism. It was also shown that the presented method performs well in the quantification of the majority of the selected NCHs in surface water with MDLs between 3 and 6 μg/L, a low matrix effect and recoveries in the range of 77–96% except for pyridazine exhibiting 32% were achieved. The method was successfully employed to follow the degradation of NCHs in ozonation.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Abdighahroudi, Mohammad Sajjad ; Lutze, Holger V. ; Schmidt, Torsten C. |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography |
| Sprache: | Englisch |
| Publikationsjahr: | 2022 |
| Publikationsdatum der Erstveröffentlichung: | 2020 |
| Verlag: | Springer |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Analytical and Bioanalytical Chemistry |
| Jahrgang/Volume einer Zeitschrift: | 412 |
| (Heft-)Nummer: | 20 |
| DOI: | 10.26083/tuprints-00013304 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/13304 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung aus DEAL-Vertrag mit Springer |
| Kurzbeschreibung (Abstract): | N-containing heterocycles (NCHs) are largely used as precursors for pharmaceuticals and can enter the environment. Some NCHs have been shown to be toxic, persistent, and very mobile in the environment. Thus, they have received increasing attention in the past years. However, the analysis of these polar compounds in environmental samples is still a challenge for liquid chromatography. This paper investigates the use of mixed-mode liquid chromatography (MMLC), which has reversed-phase and ion exchange characteristics for measurements of NCHs in water. NCHs with low pKa (i.e., < 2.5) display mainly reversed-phase interactions (neutral species) with the stationary phase and those with higher pKa (i.e., > 5) interact by a mixture of reversed-phase/ion exchange/HILIC mechanism. It was also shown that the presented method performs well in the quantification of the majority of the selected NCHs in surface water with MDLs between 3 and 6 μg/L, a low matrix effect and recoveries in the range of 77–96% except for pyridazine exhibiting 32% were achieved. The method was successfully employed to follow the degradation of NCHs in ozonation. |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-133040 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 600 Technik, Medizin, angewandte Wissenschaften > 600 Technik 600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften und Maschinenbau |
| Fachbereich(e)/-gebiet(e): | 13 Fachbereich Bau- und Umweltingenieurwissenschaften 13 Fachbereich Bau- und Umweltingenieurwissenschaften > Institut IWAR - Wasser- und Abfalltechnik, Umwelt- und Raumplanung |
| Hinterlegungsdatum: | 03 Mär 2022 13:34 |
| Letzte Änderung: | 04 Mär 2022 07:15 |
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| Suche nach Titel in: | TUfind oder in Google |
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- Development of an LC-MS method for determination of nitrogen-containing heterocycles using mixed-mode liquid chromatography. (deposited 03 Mär 2022 13:34) [Gegenwärtig angezeigt]
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