Eills, J. ; Cavallari, E. ; Kircher, R. ; Di Matteo, G. ; Carrera, C. ; Dagys, L. ; Levitt, M. H. ; Ivanov, K. L. ; Aime, S. ; Reineri, F. ; Münnemann, K. ; Budker, D. ; Buntkowsky, Gerd ; Knecht, S. (2022)
Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism.
In: Angewandte Chemie, 133 (12)
doi: 10.26083/tuprints-00020296
Artikel, Zweitveröffentlichung, Verlagsversion
Kurzbeschreibung (Abstract)
Hyperpolarization-enhanced magnetic resonance imaging can be used to study biomolecular processes in the body, but typically requires nuclei such as ¹³C, ¹⁵N, or ¹²⁹Xe due to their long spin-polarization lifetimes and the absence of a proton-background signal from water and fat in the images. Here we present a novel type of ¹H imaging, in which hyperpolarized spin order is locked in a nonmagnetic long-lived correlated (singlet) state, and is only liberated for imaging by a specific biochemical reaction. In this work we produce hyperpolarized fumarate via chemical reaction of a precursor molecule with para-enriched hydrogen gas, and the proton singlet order in fumarate is released as antiphase NMR signals by enzymatic conversion to malate in D₂O. Using this model system we show two pulse sequences to rephase the NMR signals for imaging and suppress the background signals from water. The hyperpolarization-enhanced ¹H-imaging modality presented here can allow for hyperpolarized imaging without the need for low-abundance, low-sensitivity heteronuclei.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2022 |
| Autor(en): | Eills, J. ; Cavallari, E. ; Kircher, R. ; Di Matteo, G. ; Carrera, C. ; Dagys, L. ; Levitt, M. H. ; Ivanov, K. L. ; Aime, S. ; Reineri, F. ; Münnemann, K. ; Budker, D. ; Buntkowsky, Gerd ; Knecht, S. |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Singlet-Contrast Magnetic Resonance Imaging: Unlocking Hyperpolarization with Metabolism |
| Sprache: | Englisch |
| Publikationsjahr: | 2022 |
| Verlag: | Wiley |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Angewandte Chemie |
| Jahrgang/Volume einer Zeitschrift: | 133 |
| (Heft-)Nummer: | 12 |
| DOI: | 10.26083/tuprints-00020296 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/20296 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichungsservice |
| Kurzbeschreibung (Abstract): | Hyperpolarization-enhanced magnetic resonance imaging can be used to study biomolecular processes in the body, but typically requires nuclei such as ¹³C, ¹⁵N, or ¹²⁹Xe due to their long spin-polarization lifetimes and the absence of a proton-background signal from water and fat in the images. Here we present a novel type of ¹H imaging, in which hyperpolarized spin order is locked in a nonmagnetic long-lived correlated (singlet) state, and is only liberated for imaging by a specific biochemical reaction. In this work we produce hyperpolarized fumarate via chemical reaction of a precursor molecule with para-enriched hydrogen gas, and the proton singlet order in fumarate is released as antiphase NMR signals by enzymatic conversion to malate in D₂O. Using this model system we show two pulse sequences to rephase the NMR signals for imaging and suppress the background signals from water. The hyperpolarization-enhanced ¹H-imaging modality presented here can allow for hyperpolarized imaging without the need for low-abundance, low-sensitivity heteronuclei. |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-202969 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Eduard Zintl-Institut > Fachgebiet Physikalische Chemie |
| Hinterlegungsdatum: | 10 Jan 2022 13:41 |
| Letzte Änderung: | 11 Jan 2022 06:46 |
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