Cordt, Cynthia ; Meckel, Tobias ; Geissler, Andreas ; Biesalski, Markus (2021)
Entrapment of Hydrophobic Biocides into Cellulose Acetate Nanoparticles by Nanoprecipitation.
In: Nanomaterials, 2020, 10 (12)
doi: 10.26083/tuprints-00019277
Artikel, Zweitveröffentlichung, Verlagsversion
 | Es ist eine neuere Version dieses Eintrags verfügbar. |
Kurzbeschreibung (Abstract)
This contribution reports an efficient method for the production and use of biocide-loaded cellulose acetate nanoparticles. As well-known model biocides 4-Hexylresorcinol and Triclosan were used for in situ nanoparticle loading during a nanoprecipitation process. We show that the nanoparticle size can be well-controlled by variation of the cellulose acetate concentration during nanoprecipitation. Apart from strong evidence suggesting cellulose acetate particle formation according to a nucleation-aggregation mechanism, we further show that the biocide loading of the particles occurs by a diffusion process and not via co-precipitation. The quantity of particle loading was analyzed by 1H-NMR spectroscopy of re-dissolved nanoparticles, and it was observed that a decisive factor for high packaging efficiency is the use of a biocide with low water solubility and high hydrophobicity. SEM studies showed no influence on the particle morphology or size by both biocides 4-Hexylresorcinol and Triclosan. Finally, an aqueous nanoparticle dispersion can be coated onto model paper sheets to yield pronounced antimicrobial surface-properties. Nanoparticles loaded with the biocide Triclosan showed a high antimicrobial activity against Bacillus subtilis, a cellulase producing bacteria, if applied to model paper substrates, even at extremely low coating weights of 1–5 g/m2, respectively. Additional long-term efficacy renders these nanoparticles ideal for various applications.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2021 |
| Autor(en): | Cordt, Cynthia ; Meckel, Tobias ; Geissler, Andreas ; Biesalski, Markus |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Entrapment of Hydrophobic Biocides into Cellulose Acetate Nanoparticles by Nanoprecipitation |
| Sprache: | Englisch |
| Publikationsjahr: | 2021 |
| Publikationsdatum der Erstveröffentlichung: | 2020 |
| Verlag: | MDPI |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Nanomaterials |
| Jahrgang/Volume einer Zeitschrift: | 10 |
| (Heft-)Nummer: | 12 |
| Kollation: | 15 Seiten |
| DOI: | 10.26083/tuprints-00019277 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/19277 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung aus gefördertem Golden Open Access |
| Kurzbeschreibung (Abstract): | This contribution reports an efficient method for the production and use of biocide-loaded cellulose acetate nanoparticles. As well-known model biocides 4-Hexylresorcinol and Triclosan were used for in situ nanoparticle loading during a nanoprecipitation process. We show that the nanoparticle size can be well-controlled by variation of the cellulose acetate concentration during nanoprecipitation. Apart from strong evidence suggesting cellulose acetate particle formation according to a nucleation-aggregation mechanism, we further show that the biocide loading of the particles occurs by a diffusion process and not via co-precipitation. The quantity of particle loading was analyzed by 1H-NMR spectroscopy of re-dissolved nanoparticles, and it was observed that a decisive factor for high packaging efficiency is the use of a biocide with low water solubility and high hydrophobicity. SEM studies showed no influence on the particle morphology or size by both biocides 4-Hexylresorcinol and Triclosan. Finally, an aqueous nanoparticle dispersion can be coated onto model paper sheets to yield pronounced antimicrobial surface-properties. Nanoparticles loaded with the biocide Triclosan showed a high antimicrobial activity against Bacillus subtilis, a cellulase producing bacteria, if applied to model paper substrates, even at extremely low coating weights of 1–5 g/m2, respectively. Additional long-term efficacy renders these nanoparticles ideal for various applications. |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-192775 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 540 Chemie |
| Fachbereich(e)/-gebiet(e): | 07 Fachbereich Chemie 07 Fachbereich Chemie > Ernst-Berl-Institut 07 Fachbereich Chemie > Ernst-Berl-Institut > Fachgebiet Makromolekulare Chemie |
| Hinterlegungsdatum: | 13 Aug 2021 07:10 |
| Letzte Änderung: | 03 Jul 2024 02:49 |
| PPN: | |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
- Entrapment of Hydrophobic Biocides into Cellulose Acetate Nanoparticles by Nanoprecipitation. (deposited 13 Aug 2021 07:10) [Gegenwärtig angezeigt]
 |
Frage zum Eintrag |
Optionen (nur für Redakteure)
 |
Redaktionelle Details anzeigen |
Drucken
Impressum