Hegewald, Anett B. ; Breitwieser, Kai ; Ottinger, Sarah M. ; Mobarrez, Fariborz ; Korotkova, Marina ; Rethi, Bence ; Jakobsson, Per-Johan ; Catrina, Anca I. ; Wähämaa, Heidi ; Saul, Meike J. (2021)
Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis.
In: Frontiers in Immunology, 2020, 11
doi: 10.26083/tuprints-00019253
Artikel, Zweitveröffentlichung, Verlagsversion
 | Es ist eine neuere Version dieses Eintrags verfügbar. |
Kurzbeschreibung (Abstract)
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Cell-derived small extracellular vesicles (sEV) mediate cell-to-cell communication in the synovial microenvironment by carrying microRNAs (miRs), a class of small non-coding RNAs. Herein, we report that sEV from synovial fluid promote osteoclast differentiation which is attributed to high levels of extracellular miR-574-5p. Moreover, we demonstrate for the first time that enhanced osteoclast maturation is mediated by Toll-like receptor (TLR) 7/8 signaling which is activated by miR-574-5p binding. This is a novel mechanism by which sEV and miRs contribute to RA pathogenesis and indicate that pharmacological inhibition of extracellular miR-574-5p might offer new therapeutic strategies to protect osteoclast-mediated bone destruction in RA.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2021 |
| Autor(en): | Hegewald, Anett B. ; Breitwieser, Kai ; Ottinger, Sarah M. ; Mobarrez, Fariborz ; Korotkova, Marina ; Rethi, Bence ; Jakobsson, Per-Johan ; Catrina, Anca I. ; Wähämaa, Heidi ; Saul, Meike J. |
| Art des Eintrags: | Zweitveröffentlichung |
| Titel: | Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis |
| Sprache: | Englisch |
| Publikationsjahr: | 2021 |
| Publikationsdatum der Erstveröffentlichung: | 2020 |
| Verlag: | Frontiers |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Frontiers in Immunology |
| Jahrgang/Volume einer Zeitschrift: | 11 |
| Kollation: | 14 Seiten |
| DOI: | 10.26083/tuprints-00019253 |
| URL / URN: | https://tuprints.ulb.tu-darmstadt.de/19253 |
| Zugehörige Links: | |
| Herkunft: | Zweitveröffentlichung aus gefördertem Golden Open Access |
| Kurzbeschreibung (Abstract): | Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and joint destruction. Cell-derived small extracellular vesicles (sEV) mediate cell-to-cell communication in the synovial microenvironment by carrying microRNAs (miRs), a class of small non-coding RNAs. Herein, we report that sEV from synovial fluid promote osteoclast differentiation which is attributed to high levels of extracellular miR-574-5p. Moreover, we demonstrate for the first time that enhanced osteoclast maturation is mediated by Toll-like receptor (TLR) 7/8 signaling which is activated by miR-574-5p binding. This is a novel mechanism by which sEV and miRs contribute to RA pathogenesis and indicate that pharmacological inhibition of extracellular miR-574-5p might offer new therapeutic strategies to protect osteoclast-mediated bone destruction in RA. |
| Status: | Verlagsversion |
| URN: | urn:nbn:de:tuda-tuprints-192537 |
| Sachgruppe der Dewey Dezimalklassifikatin (DDC): | 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften, Biologie |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Extracellular vesicles / miRNA Research |
| Hinterlegungsdatum: | 04 Aug 2021 08:05 |
| Letzte Änderung: | 10 Aug 2021 13:50 |
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| Suche nach Titel in: | TUfind oder in Google |
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- Extracellular miR-574-5p Induces Osteoclast Differentiation via TLR 7/8 in Rheumatoid Arthritis. (deposited 04 Aug 2021 08:05) [Gegenwärtig angezeigt]
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