Kemmerer, Katrin ; Fischer, Sandra ; Weigand, Julia E. (2018)
Auto- and cross-regulation of the hnRNPs D and DL.
In: RNA (New York, N.Y.), 24 (3)
doi: 10.1261/rna.063420.117
Artikel, Bibliographie
Kurzbeschreibung (Abstract)
HnRNP D, better known as AUF1, is an extensively studied protein that controls a variety of cellular pathways. Consequently, its expression has to be tightly regulated to prevent the onset of pathologies. In contrast, the cellular functions and regulation of its ubiquitously expressed paralog hnRNP DL are barely explored. Here, we present an intricate crosstalk between these two proteins. Both hnRNP D and DL are able to control their own expression by alternative splicing of cassette exons in their 3'UTRs. Exon inclusion produces mRNAs degraded by nonsense-mediated decay. Moreover, hnRNP D and DL control the expression of one another by the same mechanism. Thus, we identified two novel ways of how hnRNP D expression is controlled. The tight interconnection of expression control directly links hnRNP DL to hnRNP D-related diseases and emphasizes the importance of a systematic analysis of its cellular functions.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2018 |
| Autor(en): | Kemmerer, Katrin ; Fischer, Sandra ; Weigand, Julia E. |
| Art des Eintrags: | Bibliographie |
| Titel: | Auto- and cross-regulation of the hnRNPs D and DL |
| Sprache: | Englisch |
| Publikationsjahr: | März 2018 |
| Verlag: | Cold Spring Harbor Laboratory Press / RNA Society |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | RNA (New York, N.Y.) |
| Jahrgang/Volume einer Zeitschrift: | 24 |
| (Heft-)Nummer: | 3 |
| DOI: | 10.1261/rna.063420.117 |
| URL / URN: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824352/ |
| Kurzbeschreibung (Abstract): | HnRNP D, better known as AUF1, is an extensively studied protein that controls a variety of cellular pathways. Consequently, its expression has to be tightly regulated to prevent the onset of pathologies. In contrast, the cellular functions and regulation of its ubiquitously expressed paralog hnRNP DL are barely explored. Here, we present an intricate crosstalk between these two proteins. Both hnRNP D and DL are able to control their own expression by alternative splicing of cassette exons in their 3'UTRs. Exon inclusion produces mRNAs degraded by nonsense-mediated decay. Moreover, hnRNP D and DL control the expression of one another by the same mechanism. Thus, we identified two novel ways of how hnRNP D expression is controlled. The tight interconnection of expression control directly links hnRNP DL to hnRNP D-related diseases and emphasizes the importance of a systematic analysis of its cellular functions. |
| ID-Nummer: | pmid:29263134 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > RNA Biochemie |
| Hinterlegungsdatum: | 05 Mär 2021 07:41 |
| Letzte Änderung: | 05 Mär 2021 07:41 |
| PPN: | |
| Export: | |
| Suche nach Titel in: | TUfind oder in Google |
 |
Frage zum Eintrag |
Optionen (nur für Redakteure)
 |
Redaktionelle Details anzeigen |
Drucken
Impressum