Cordt, Cynthia ; Meckel, Tobias ; Geissler, Andreas ; Biesalski, Markus (2020)
Entrapment of hydrophobic biocides into cellulose acetate nanoparticles by nanoprecipitation.
In: Nanomaterials (Basel, Switzerland), 10 (12)
doi: 10.3390/nano10122447
Artikel, Bibliographie
Dies ist die neueste Version dieses Eintrags.
Kurzbeschreibung (Abstract)
This contribution reports an efficient method for the production and use of biocide-loaded cellulose acetate nanoparticles. As well-known model biocides 4-Hexylresorcinol and Triclosan were used for in situ nanoparticle loading during a nanoprecipitation process. We show that the nanoparticle size can be well-controlled by variation of the cellulose acetate concentration during nanoprecipitation. Apart from strong evidence suggesting cellulose acetate particle formation according to a nucleation-aggregation mechanism, we further show that the biocide loading of the particles occurs by a diffusion process and not via co-precipitation. The quantity of particle loading was analyzed by H-NMR spectroscopy of re-dissolved nanoparticles, and it was observed that a decisive factor for high packaging efficiency is the use of a biocide with low water solubility and high hydrophobicity. SEM studies showed no influence on the particle morphology or size by both biocides 4-Hexylresorcinol and Triclosan. Finally, an aqueous nanoparticle dispersion can be coated onto model paper sheets to yield pronounced antimicrobial surface-properties. Nanoparticles loaded with the biocide Triclosan showed a high antimicrobial activity against , a cellulase producing bacteria, if applied to model paper substrates, even at extremely low coating weights of 1-5 g/m, respectively. Additional long-term efficacy renders these nanoparticles ideal for various applications.
| Typ des Eintrags: | Artikel |
|---|---|
| Erschienen: | 2020 |
| Autor(en): | Cordt, Cynthia ; Meckel, Tobias ; Geissler, Andreas ; Biesalski, Markus |
| Art des Eintrags: | Bibliographie |
| Titel: | Entrapment of hydrophobic biocides into cellulose acetate nanoparticles by nanoprecipitation. |
| Sprache: | Englisch |
| Publikationsjahr: | 7 Dezember 2020 |
| Titel der Zeitschrift, Zeitung oder Schriftenreihe: | Nanomaterials (Basel, Switzerland) |
| Jahrgang/Volume einer Zeitschrift: | 10 |
| (Heft-)Nummer: | 12 |
| DOI: | 10.3390/nano10122447 |
| Zugehörige Links: | |
| Kurzbeschreibung (Abstract): | This contribution reports an efficient method for the production and use of biocide-loaded cellulose acetate nanoparticles. As well-known model biocides 4-Hexylresorcinol and Triclosan were used for in situ nanoparticle loading during a nanoprecipitation process. We show that the nanoparticle size can be well-controlled by variation of the cellulose acetate concentration during nanoprecipitation. Apart from strong evidence suggesting cellulose acetate particle formation according to a nucleation-aggregation mechanism, we further show that the biocide loading of the particles occurs by a diffusion process and not via co-precipitation. The quantity of particle loading was analyzed by H-NMR spectroscopy of re-dissolved nanoparticles, and it was observed that a decisive factor for high packaging efficiency is the use of a biocide with low water solubility and high hydrophobicity. SEM studies showed no influence on the particle morphology or size by both biocides 4-Hexylresorcinol and Triclosan. Finally, an aqueous nanoparticle dispersion can be coated onto model paper sheets to yield pronounced antimicrobial surface-properties. Nanoparticles loaded with the biocide Triclosan showed a high antimicrobial activity against , a cellulase producing bacteria, if applied to model paper substrates, even at extremely low coating weights of 1-5 g/m, respectively. Additional long-term efficacy renders these nanoparticles ideal for various applications. |
| ID-Nummer: | pmid:33297450 |
| Fachbereich(e)/-gebiet(e): | 10 Fachbereich Biologie 10 Fachbereich Biologie > Membrane Dynamics |
| Hinterlegungsdatum: | 14 Dez 2020 13:10 |
| Letzte Änderung: | 03 Jul 2024 02:49 |
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| Suche nach Titel in: | TUfind oder in Google |
Verfügbare Versionen dieses Eintrags
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Entrapment of Hydrophobic Biocides into Cellulose Acetate Nanoparticles by Nanoprecipitation. (deposited 13 Aug 2021 07:10)
- Entrapment of hydrophobic biocides into cellulose acetate nanoparticles by nanoprecipitation. (deposited 14 Dez 2020 13:10) [Gegenwärtig angezeigt]
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