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Genetic Diversity of Potassium Ion Channel Proteins Encoded by Chloroviruses That Infect Chlorella heliozoae

Murry, Carter R. ; Agarkova, Irina V. ; Ghosh, Jayadri S. ; Fitzgerald, Fiona C. ; Carlson, Roger M. ; Hertel, Brigitte ; Kukovetz, Kerri ; Rauh, Oliver ; Thiel, Gerhard ; Etten, James L. van (2020)
Genetic Diversity of Potassium Ion Channel Proteins Encoded by Chloroviruses That Infect Chlorella heliozoae.
In: Viruses, 12 (6)
doi: 10.3390/v12060678
Artikel, Bibliographie

Kurzbeschreibung (Abstract)

Chloroviruses are large, plaque-forming, dsDNA viruses that infect chlorella-like green algae that live in a symbiotic relationship with protists. Chloroviruses have genomes from 290 to 370 kb, and they encode as many as 400 proteins. One interesting feature of chloroviruses is that they encode a potassium ion (K) channel protein named Kcv. The Kcv protein encoded by SAG chlorovirus ATCV-1 is one of the smallest known functional K channel proteins consisting of 82 amino acids. The Kcv protein has similarities to the family of two transmembrane domain K channel proteins; it consists of two transmembrane α-helixes with a pore region in the middle, making it an ideal model for studying K channels. To assess their genetic diversity, genes were sequenced from 103 geographically distinct SAG chlorovirus isolates. Of the 103 genes, there were 42 unique DNA sequences that translated into 26 new Kcv channels. The new predicted Kcv proteins differed from Kcv by 1 to 55 amino acids. The most conserved region of the Kcv protein was the filter, the turret and the pore helix were fairly well conserved, and the outer and the inner transmembrane domains of the protein were the most variable. Two of the new predicted channels were shown to be functional K channels.

Typ des Eintrags: Artikel
Erschienen: 2020
Autor(en): Murry, Carter R. ; Agarkova, Irina V. ; Ghosh, Jayadri S. ; Fitzgerald, Fiona C. ; Carlson, Roger M. ; Hertel, Brigitte ; Kukovetz, Kerri ; Rauh, Oliver ; Thiel, Gerhard ; Etten, James L. van
Art des Eintrags: Bibliographie
Titel: Genetic Diversity of Potassium Ion Channel Proteins Encoded by Chloroviruses That Infect Chlorella heliozoae
Sprache: Englisch
Publikationsjahr: 23 Juni 2020
Titel der Zeitschrift, Zeitung oder Schriftenreihe: Viruses
Jahrgang/Volume einer Zeitschrift: 12
(Heft-)Nummer: 6
DOI: 10.3390/v12060678
Kurzbeschreibung (Abstract):

Chloroviruses are large, plaque-forming, dsDNA viruses that infect chlorella-like green algae that live in a symbiotic relationship with protists. Chloroviruses have genomes from 290 to 370 kb, and they encode as many as 400 proteins. One interesting feature of chloroviruses is that they encode a potassium ion (K) channel protein named Kcv. The Kcv protein encoded by SAG chlorovirus ATCV-1 is one of the smallest known functional K channel proteins consisting of 82 amino acids. The Kcv protein has similarities to the family of two transmembrane domain K channel proteins; it consists of two transmembrane α-helixes with a pore region in the middle, making it an ideal model for studying K channels. To assess their genetic diversity, genes were sequenced from 103 geographically distinct SAG chlorovirus isolates. Of the 103 genes, there were 42 unique DNA sequences that translated into 26 new Kcv channels. The new predicted Kcv proteins differed from Kcv by 1 to 55 amino acids. The most conserved region of the Kcv protein was the filter, the turret and the pore helix were fairly well conserved, and the outer and the inner transmembrane domains of the protein were the most variable. Two of the new predicted channels were shown to be functional K channels.

ID-Nummer: pmid:32585987
Fachbereich(e)/-gebiet(e): 10 Fachbereich Biologie
10 Fachbereich Biologie > Plant Membrane Biophyscis (am 20.12.23 umbenannt in Biologie der Algen und Protozoen)
Hinterlegungsdatum: 29 Jun 2020 11:32
Letzte Änderung: 20 Aug 2021 09:43
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