Ensinger, Wolfgang (2018)
Development of a Biomolecular Analyzer Based on Ion-conducting Nanopores: The iNAPO Project.
3rd World Congress on Recent Advances in Nanotechnology (RAN'18). Budapest, Hungary (10.04.2018-12.04.2018)
doi: 10.11159/icnb18.104
Konferenzveröffentlichung, Bibliographie
Kurzbeschreibung (Abstract)
Analyzing biologically relevant molecules is an important aspect of medical diagnostics. The iNAPO project aims at developing a device that is able to specifically detect and quantitatively analyze biomolecules. An example is tumor markers that are emitted by the tumor at elevated levels and can be found in body liquids. The analyzer device core consists of a polymer foil containing a nanopore. In analogy to biological nanopores that control e.g. mass transfer into and out of a cell, the biomimetic artificial nanopore allows the passage of ions of an aqueous electrolyte in an electrochemical two - compartment cell from one compartment to the next one under the influence of an electrical field. When the nanopore wall contains certain immobilized molecules that specifically react with the biomolecules to be analyzed, the ionic current is influenced. The difference in th e current can directly be correlated to the presence and the quantity of the biomolecule. As an example, the measurement of small quantities of histamine, the well known neurotransmitter, is shown.
| Typ des Eintrags: | Konferenzveröffentlichung |
|---|---|
| Erschienen: | 2018 |
| Autor(en): | Ensinger, Wolfgang |
| Art des Eintrags: | Bibliographie |
| Titel: | Development of a Biomolecular Analyzer Based on Ion-conducting Nanopores: The iNAPO Project |
| Sprache: | Englisch |
| Publikationsjahr: | 2018 |
| Buchtitel: | Proceedings of the 3rd World Congress on Recent Advances in Nanotechnology |
| Veranstaltungstitel: | 3rd World Congress on Recent Advances in Nanotechnology (RAN'18) |
| Veranstaltungsort: | Budapest, Hungary |
| Veranstaltungsdatum: | 10.04.2018-12.04.2018 |
| DOI: | 10.11159/icnb18.104 |
| URL / URN: | https://doi.org/10.11159/icnb18.104 |
| Kurzbeschreibung (Abstract): | Analyzing biologically relevant molecules is an important aspect of medical diagnostics. The iNAPO project aims at developing a device that is able to specifically detect and quantitatively analyze biomolecules. An example is tumor markers that are emitted by the tumor at elevated levels and can be found in body liquids. The analyzer device core consists of a polymer foil containing a nanopore. In analogy to biological nanopores that control e.g. mass transfer into and out of a cell, the biomimetic artificial nanopore allows the passage of ions of an aqueous electrolyte in an electrochemical two - compartment cell from one compartment to the next one under the influence of an electrical field. When the nanopore wall contains certain immobilized molecules that specifically react with the biomolecules to be analyzed, the ionic current is influenced. The difference in th e current can directly be correlated to the presence and the quantity of the biomolecule. As an example, the measurement of small quantities of histamine, the well known neurotransmitter, is shown. |
| Freie Schlagworte: | Nanopores, Ion Conduction, Track Etching Technique, Biomolecular Sensor, Neurotransmitter, Histamine |
| Fachbereich(e)/-gebiet(e): | 11 Fachbereich Material- und Geowissenschaften 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft 11 Fachbereich Material- und Geowissenschaften > Materialwissenschaft > Fachgebiet Materialanalytik |
| Hinterlegungsdatum: | 11 Dez 2018 12:41 |
| Letzte Änderung: | 11 Dez 2018 12:41 |
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