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Mesic, Ivana ; Madry, Christian ; Geider, Kirsten ; Bernhard, Max ; Betz, Heinrich ; Laube, Bodo (2016):
The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors.
In: Neuropharmacology, 105, pp. 133-141. ISSN 1873-7064,
[Article]
Dutertre, Sébastien ; Drwal, Malgorzata ; Laube, Bodo ; Betz, Heinrich (2012):
Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist binding site.
In: Journal of neurochemistry, 122 (1), pp. 38-47. ISSN 1471-4159,
[Article]
Kallenborn-Gerhardt, Wiebke ; Lu, Ruirui ; Lorenz, Jana ; Gao, Wei ; Weiland, Jessica ; Del Turco, Domenico ; Deller, Thomas ; Laube, Bodo ; Betz, Heinrich ; Geisslinger, Gerd ; Schmidtko, Achim (2012):
Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2.
In: Behavioural brain research, 226 (1), pp. 106-11. ISSN 1872-7549,
[Article]
Madry, Christian ; Betz, Heinrich ; Geiger, Jörg R. P. ; Laube, Bodo (2010):
Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification.
In: Frontiers in molecular neuroscience, 3, p. 6. ISSN 1662-5099,
[Article]
Haeger, Svenja ; Kuzmin, Dmitry ; Detro-Dassen, Silvia ; Lang, Niklas ; Kilb, Michael ; Tsetlin, Victor ; Betz, Heinrich ; Laube, Bodo ; Schmalzing, Günther (2010):
An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors.
In: Nature structural & molecular biology, 17 (1), pp. 90-8. ISSN 1545-9985,
[Article]
Schumann, Tanja ; Grudzinska, Joanna ; Kuzmin, Dmitry ; Betz, Heinrich ; Laube, Bodo (2009):
Binding-site mutations in the alpha1 subunit of the inhibitory glycine receptor convert the inhibitory metal ion Cu2+ into a positive modulator.
In: Neuropharmacology, 56 (1), pp. 310-7. ISSN 0028-3908,
[Article]
Laube, Bodo ; Betz, Heinrich (2009):
Die duale Rolle des Neurotransmitters Glyzin im zentralen Nervensystem.
In: Jahrbuch 2009 der Max-Planck-Gesellschaft, [Article]
Maksay, Gábor ; Laube, Bodo ; Schemm, Rudolf ; Grudzinska, Joanna ; Drwal, Malgorzata ; Betz, Heinrich (2009):
Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors.
In: Journal of neurochemistry, 109 (6), pp. 1725-32. ISSN 1471-4159,
[Article]
Grudzinska, Joanna ; Schumann, Tanja ; Schemm, Rudolf ; Betz, Heinrich ; Laube, Bodo (2008):
Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel.
In: Channels (Austin, Tex.), 2 (1), pp. 13-8. ISSN 1933-6969,
[Article]
Madry, Christian ; Betz, Heinrich ; Geiger, Jörg R. P. ; Laube, Bodo (2008):
Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.
In: Proceedings of the National Academy of Sciences of the United States of America, 105 (34), pp. 12563-8. ISSN 1091-6490,
[Article]
Papadopoulos, Theofilos ; Korte, Martin ; Eulenburg, Volker ; Kubota, Hisahiko ; Retiounskaia, Marina ; Harvey, Robert J. ; Harvey, Kirsten ; O'Sullivan, Gregory A. ; Laube, Bodo ; Hülsmann, Swen ; Geiger, Jörg R. P. ; Betz, Heinrich (2007):
Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice.
In: The EMBO journal, 26 (17), pp. 3888-99. ISSN 0261-4189,
[Article]
Madry, Christian ; Mesic, Ivana ; Betz, Heinrich ; Laube, Bodo (2007):
The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors.
In: Molecular pharmacology, 72 (6), pp. 1535-44. ISSN 1521-0111,
[Article]
Madry, Christian ; Mesic, Ivana ; Bartholomäus, Ingo ; Nicke, Annette ; Betz, Heinrich ; Laube, Bodo (2007):
Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function.
In: Biochemical and biophysical research communications, 354 (1), pp. 102-8. ISSN 0006-291X,
[Article]
Betz, Heinrich ; Laube, Bodo (2006):
Glycine receptors: recent insights into their structural organization and functional diversity.
In: Journal of neurochemistry, 97 (6), pp. 1600-10. ISSN 0022-3042,
[Article]
Hirzel, Klaus ; Müller, Ulrike ; Latal, A.Tobias ; Hülsmann, Swen ; Grudzinska, Joanna ; Seeliger, Mathias W. ; Betz, Heinrich ; Laube, Bodo (2006):
Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission.
In: Neuron, 52 (4), pp. 679-90. ISSN 0896-6273,
[Article]
Grudzinska, Joanna ; Schemm, Rudolf ; Haeger, Svenja ; Nicke, Annette ; Schmalzing, Guenther ; Betz, Heinrich ; Laube, Bodo (2005):
The beta subunit determines the ligand binding properties of synaptic glycine receptors.
In: Neuron, 45 (5), pp. 727-39. ISSN 0896-6273,
[Article]
Kondratskaya, Elena L. ; Betz, Heinrich ; Krishtal, Oleg A. ; Laube, Bodo (2005):
The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors.
In: Neuropharmacology, 49 (6), pp. 945-51. ISSN 0028-3908,
[Article]
Laube, Bodo ; Schemm, Rudolf ; Betz, Heinrich (2004):
Molecular determinants of ligand discrimination in the glutamate-binding pocket of the NMDA receptor.
In: Neuropharmacology, 47 (7), pp. 994-1007. ISSN 0028-3908,
[Article]
O'Shea, Sean Michael ; Becker, Lore ; Weiher, Hans ; Betz, Heinrich ; Laube, Bodo (2004):
Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice.
In: The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 (9), pp. 2322-7. ISSN 1529-2401,
[Article]
Gomeza, Jesús ; Ohno, Koji ; Hülsmann, Swen ; Armsen, Wencke ; Eulenburg, Volker ; Richter, Diethelm W. ; Laube, Bodo ; Betz, Heinrich (2003):
Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality.
In: Neuron, 40 (4), pp. 797-806. ISSN 0896-6273,
[Article]
Foucaud, Bernard ; Laube, Bodo ; Schemm, Rudolf ; Kreimeyer, Annett ; Goeldner, Maurice ; Betz, Heinrich (2003):
Structural model of the N-methyl-D-aspartate receptor glycine site probed by site-directed chemical coupling.
In: The Journal of biological chemistry, 278 (26), pp. 24011-7. ISSN 0021-9258,
[Article]
Sadtler, Sven ; Laube, Bodo ; Lashub, Alhassan ; Nicke, Annette ; Betz, Heinrich ; Schmalzing, Günther (2003):
A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunit.
In: The Journal of biological chemistry, 278 (19), pp. 16782-90. ISSN 0021-9258,
[Article]
Laube, Bodo ; Maksay, Gábor ; Schemm, Rudolf ; Betz, Heinrich (2002):
Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?
In: Trends in pharmacological sciences, 23 (11), pp. 519-27. ISSN 0165-6147,
[Article]