Simoniello, Palma ; Wiedemann, Julia ; Zink, Joana ; Thoennes, Eva ; Stange, Maike ; Layer, Paul G. ; Kovacs, Maximilian ; Podda, Maurizio ; Durante, Marco ; Fournier, Claudia (2016)
Exposure to carbon ions triggers proinflammatory signals and changes in homeostasis and epidermal tissue organization to a similar extent as photons.
In: Frontiers in oncology, 5
doi: 10.3389/fonc.2015.00294
Article, Bibliographie
This is the latest version of this item.
Abstract
The increasing application of charged particles in radiotherapy requires a deeper understanding of early and late side effects occurring in skin, which is exposed in all radiation treatments. We measured cellular and molecular changes related to the early inflammatory response of human skin irradiated with carbon ions, in particular cell death induction and changes in differentiation and proliferation of epidermal cells during the first days after exposure. Model systems for human skin from healthy donors of different complexity, i.e., keratinocytes, coculture of skin cells, 3D skin equivalents, and skin explants, were used to investigate the alterations induced by carbon ions (spread-out Bragg peak, dose-averaged LET 100 keV/μm) in comparison to X-ray and UV-B exposure. After exposure to ionizing radiation, in none of the model systems, apoptosis/necrosis was observed. Carbon ions triggered inflammatory signaling and accelerated differentiation of keratinocytes to a similar extent as X-rays at the same doses. High doses of carbon ions were more effective than X-rays in reducing proliferation and inducing abnormal differentiation. In contrast, changes identified following low-dose exposure (≤0.5 Gy) were induced more effectively after X-ray exposure, i.e., enhanced proliferation and change in the polarity of basal cells.
| Item Type: | Article |
|---|---|
| Erschienen: | 2016 |
| Creators: | Simoniello, Palma ; Wiedemann, Julia ; Zink, Joana ; Thoennes, Eva ; Stange, Maike ; Layer, Paul G. ; Kovacs, Maximilian ; Podda, Maurizio ; Durante, Marco ; Fournier, Claudia |
| Type of entry: | Bibliographie |
| Title: | Exposure to carbon ions triggers proinflammatory signals and changes in homeostasis and epidermal tissue organization to a similar extent as photons |
| Language: | English |
| Date: | 2016 |
| Publisher: | Frontiers Media S.A. |
| Journal or Publication Title: | Frontiers in oncology |
| Volume of the journal: | 5 |
| DOI: | 10.3389/fonc.2015.00294 |
| Corresponding Links: | |
| Abstract: | The increasing application of charged particles in radiotherapy requires a deeper understanding of early and late side effects occurring in skin, which is exposed in all radiation treatments. We measured cellular and molecular changes related to the early inflammatory response of human skin irradiated with carbon ions, in particular cell death induction and changes in differentiation and proliferation of epidermal cells during the first days after exposure. Model systems for human skin from healthy donors of different complexity, i.e., keratinocytes, coculture of skin cells, 3D skin equivalents, and skin explants, were used to investigate the alterations induced by carbon ions (spread-out Bragg peak, dose-averaged LET 100 keV/μm) in comparison to X-ray and UV-B exposure. After exposure to ionizing radiation, in none of the model systems, apoptosis/necrosis was observed. Carbon ions triggered inflammatory signaling and accelerated differentiation of keratinocytes to a similar extent as X-rays at the same doses. High doses of carbon ions were more effective than X-rays in reducing proliferation and inducing abnormal differentiation. In contrast, changes identified following low-dose exposure (≤0.5 Gy) were induced more effectively after X-ray exposure, i.e., enhanced proliferation and change in the polarity of basal cells. |
| Divisions: | 10 Department of Biology 10 Department of Biology > Developmental Biology and Neurogenetics 10 Department of Biology > Radiation Biology and DNA Repair 05 Department of Physics 05 Department of Physics > Institute for Condensed Matter Physics |
| Date Deposited: | 28 Jan 2016 07:09 |
| Last Modified: | 21 Mar 2024 07:50 |
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| Suche nach Titel in: | TUfind oder in Google |
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Exposure to Carbon Ions Triggers Proinflammatory Signals and Changes in Homeostasis and Epidermal Tissue Organization to a Similar Extent as Photons. (deposited 08 Mar 2024 13:13)
- Exposure to carbon ions triggers proinflammatory signals and changes in homeostasis and epidermal tissue organization to a similar extent as photons. (deposited 28 Jan 2016 07:09) [Currently Displayed]
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