Plaumann, M. ; Bommerich, U. ; Trantzschel, T. ; Lego, D. ; Dillenberger, S. ; Sauer, G. ; Bargon, J. ; Buntkowsky, G. ; Bernarding, J. (2013)
Parahydrogen-Induced Polarization Transfer to F-19 in Perfluorocarbons for F-19 NMR Spectroscopy and MRI.
In: Chemistry-a European Journal, 19 (20)
Article, Bibliographie
Abstract
Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen-induced polarization (PHIP) is applied to enhance 19FMR signals of (perfluoro-n-hexyl)ethene and (perfluoro-n-hexyl)ethane. Unexpectedly, the end-standing CF3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non-intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and 19F19FNOESY spectra, as well as 19F T1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF3 group, first 19FMR images of hyperpolarized linear semifluorinated alkenes were recorded.
| Item Type: | Article |
|---|---|
| Erschienen: | 2013 |
| Creators: | Plaumann, M. ; Bommerich, U. ; Trantzschel, T. ; Lego, D. ; Dillenberger, S. ; Sauer, G. ; Bargon, J. ; Buntkowsky, G. ; Bernarding, J. |
| Type of entry: | Bibliographie |
| Title: | Parahydrogen-Induced Polarization Transfer to F-19 in Perfluorocarbons for F-19 NMR Spectroscopy and MRI |
| Language: | English |
| Date: | 2013 |
| Journal or Publication Title: | Chemistry-a European Journal |
| Volume of the journal: | 19 |
| Issue Number: | 20 |
| URL / URN: | http://apps.webofknowledge.com/full_record.do?product=WOS&se... |
| Abstract: | Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen-induced polarization (PHIP) is applied to enhance 19FMR signals of (perfluoro-n-hexyl)ethene and (perfluoro-n-hexyl)ethane. Unexpectedly, the end-standing CF3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non-intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and 19F19FNOESY spectra, as well as 19F T1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF3 group, first 19FMR images of hyperpolarized linear semifluorinated alkenes were recorded. |
| Uncontrolled Keywords: | fluorine hydrogenation imaging agents nmr spectroscopy polarization transfer magnetic-resonance para-hydrogen c-13 hyperpolarization enhancement metabolism alignment spectra agents noesy |
| Additional Information: | 136ME Times Cited:6 Cited References Count:42 |
| Divisions: | 07 Department of Chemistry 07 Department of Chemistry > Eduard Zintl-Institut > Physical Chemistry |
| Date Deposited: | 27 Oct 2014 20:47 |
| Last Modified: | 29 May 2019 11:00 |
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