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Riboswitch engineering - making the all-important second and third steps.

Berens, Christian ; Suess, Beatrix (2015):
Riboswitch engineering - making the all-important second and third steps.
In: Current opinion in biotechnology, 31, pp. 10-15. ISSN 1879-0429,
[Article]

Abstract

Synthetic biology uses our understanding of biological systems to develop innovative solutions for challenges in fields as diverse as genetic control and logic devices, bioremediation, materials production or diagnostics and therapy in medicine by designing new biological components. RNA-based elements are key components of these engineered systems. Their structural and functional diversity is ideal for generating regulatory riboswitches that react with many different types of output to molecular and environmental signals. Recent advances have added new sensor and output domains to the existing toolbox, and demonstrated the portability of riboswitches to many different organisms. Improvements in riboswitch design and screens for selecting in vivo active switches provide the means to isolate riboswitches with regulatory properties more like their natural counterparts.

Item Type: Article
Erschienen: 2015
Creators: Berens, Christian ; Suess, Beatrix
Title: Riboswitch engineering - making the all-important second and third steps.
Language: English
Abstract:

Synthetic biology uses our understanding of biological systems to develop innovative solutions for challenges in fields as diverse as genetic control and logic devices, bioremediation, materials production or diagnostics and therapy in medicine by designing new biological components. RNA-based elements are key components of these engineered systems. Their structural and functional diversity is ideal for generating regulatory riboswitches that react with many different types of output to molecular and environmental signals. Recent advances have added new sensor and output domains to the existing toolbox, and demonstrated the portability of riboswitches to many different organisms. Improvements in riboswitch design and screens for selecting in vivo active switches provide the means to isolate riboswitches with regulatory properties more like their natural counterparts.

Journal or Publication Title: Current opinion in biotechnology
Journal volume: 31
Divisions: 10 Department of Biology
10 Department of Biology > Synthetic Genetic Circuits
Date Deposited: 03 Sep 2014 08:40
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