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Synthetic riboswitches - A tool comes of age.

Groher, Florian ; Suess, Beatrix (2014):
Synthetic riboswitches - A tool comes of age.
In: Biochimica et biophysica acta - Gene regulation mechanisms, 1839 (10), pp. 964-973. ISSN 0006-3002,
[Article]

Abstract

Within the last decade, it has become obvious that RNA plays an important role in regulating gene expression. This has led to a plethora of approaches aiming at exploiting the outstanding chemical properties of RNA to develop artificial RNA regulators for conditional gene expression systems. Consequently, many different regulators have been developed to act on various stages of gene expression. They can be engineered to respond to almost any ligand of choice and are, therefore, of great interest for applications in synthetic biology. This review presents an overview of such engineered riboswitches, discusses their applicability and points out recent trends in their development. This article is part of a Special Issue entitled: Riboswitches.

Item Type: Article
Erschienen: 2014
Creators: Groher, Florian ; Suess, Beatrix
Title: Synthetic riboswitches - A tool comes of age.
Language: English
Abstract:

Within the last decade, it has become obvious that RNA plays an important role in regulating gene expression. This has led to a plethora of approaches aiming at exploiting the outstanding chemical properties of RNA to develop artificial RNA regulators for conditional gene expression systems. Consequently, many different regulators have been developed to act on various stages of gene expression. They can be engineered to respond to almost any ligand of choice and are, therefore, of great interest for applications in synthetic biology. This review presents an overview of such engineered riboswitches, discusses their applicability and points out recent trends in their development. This article is part of a Special Issue entitled: Riboswitches.

Journal or Publication Title: Biochimica et biophysica acta - Gene regulation mechanisms
Journal volume: 1839
Number: 10
Divisions: 10 Department of Biology
10 Department of Biology > Synthetic Genetic Circuits
Date Deposited: 27 May 2014 11:14
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