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An RNA G-quadruplex in the 3' UTR of the proto-oncogene PIM1 represses translation.

Arora, Amit ; Suess, Beatrix (2011):
An RNA G-quadruplex in the 3' UTR of the proto-oncogene PIM1 represses translation.
In: RNA biology, 8 (5), ISSN 1555-8584,
[Article]

Abstract

We have identified a conserved G-quadruplex forming sequence in the 3' untranslated region (UTR) of the proto-oncogene PIM1. Circular dichroism and thermal denaturation studies revealed that the PIM1 mRNA guanine-rich sequence forms a highly stable intramolecular G-quadruplex structure. Reporter gene assay demonstrated that the PIM1 RNA G-quadruplex represses translation. It is the first experimental evidence of an RNA G-quadruplex structure located in the 3' UTR that may act as posttranscriptional regulator.

Item Type: Article
Erschienen: 2011
Creators: Arora, Amit ; Suess, Beatrix
Title: An RNA G-quadruplex in the 3' UTR of the proto-oncogene PIM1 represses translation.
Language: English
Abstract:

We have identified a conserved G-quadruplex forming sequence in the 3' untranslated region (UTR) of the proto-oncogene PIM1. Circular dichroism and thermal denaturation studies revealed that the PIM1 mRNA guanine-rich sequence forms a highly stable intramolecular G-quadruplex structure. Reporter gene assay demonstrated that the PIM1 RNA G-quadruplex represses translation. It is the first experimental evidence of an RNA G-quadruplex structure located in the 3' UTR that may act as posttranscriptional regulator.

Journal or Publication Title: RNA biology
Journal volume: 8
Number: 5
Divisions: 10 Department of Biology > Synthetic Genetic Circuits
10 Department of Biology
Date Deposited: 22 Feb 2012 10:13
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