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Spatial and temporal expression patterns of GDNF family receptor alpha4 in the developing chicken retina.

Rothermel, Andrée and Volpert, Katja and Schlichting, Ralf and Huhn, Jutta and Stotz-Reimers, Meike and Robitzki, Andrea A. and Layer, Paul G. (2004):
Spatial and temporal expression patterns of GDNF family receptor alpha4 in the developing chicken retina.
In: Gene expression patterns : GEP, 4 (1), pp. 59-63. ISSN 1567-133X,
[Article]

Abstract

GDNF family receptor alpha (GFRalpha) receptors are involved in the regulation of different aspects of embryonic development such as proliferation, migration, differentiation and survival. To determine the possible role of GFRalpha4 in retinal development, we analysed its expression in the developing chicken retina. We found that GFRalpha4 is temporally co-expressed with c-ret. Both, the temporal and spatial expression of GFRalpha4 is developmentally regulated during retinogenesis and is first detected in cells of the ganglion cell layer at E6. As development of the retina proceeds, the expression of GFRalpha4 extends to cells of the inner half of the inner nuclear layer and to cells of the outermost cell row of the inner nuclear layer. Later on, GFRalpha4 expression is also found in additional cells of the outer half of the inner nuclear layer and in a subpopulation of photoreceptors. A central-to-peripheral gradient of retinal differentiation is evident, as the onset of GFRalpha4 expression is first detectable in the central retina, while it is delayed by two days in its periphery.

Item Type: Article
Erschienen: 2004
Creators: Rothermel, Andrée and Volpert, Katja and Schlichting, Ralf and Huhn, Jutta and Stotz-Reimers, Meike and Robitzki, Andrea A. and Layer, Paul G.
Title: Spatial and temporal expression patterns of GDNF family receptor alpha4 in the developing chicken retina.
Language: English
Abstract:

GDNF family receptor alpha (GFRalpha) receptors are involved in the regulation of different aspects of embryonic development such as proliferation, migration, differentiation and survival. To determine the possible role of GFRalpha4 in retinal development, we analysed its expression in the developing chicken retina. We found that GFRalpha4 is temporally co-expressed with c-ret. Both, the temporal and spatial expression of GFRalpha4 is developmentally regulated during retinogenesis and is first detected in cells of the ganglion cell layer at E6. As development of the retina proceeds, the expression of GFRalpha4 extends to cells of the inner half of the inner nuclear layer and to cells of the outermost cell row of the inner nuclear layer. Later on, GFRalpha4 expression is also found in additional cells of the outer half of the inner nuclear layer and in a subpopulation of photoreceptors. A central-to-peripheral gradient of retinal differentiation is evident, as the onset of GFRalpha4 expression is first detectable in the central retina, while it is delayed by two days in its periphery.

Journal or Publication Title: Gene expression patterns : GEP
Journal volume: 4
Number: 1
Divisions: 10 Department of Biology
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10 Department of Biology > Developmental Biology and Neurogenetics
Date Deposited: 21 Nov 2011 10:11
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